Abstract 15899: The Combination of Increased Non-Apoptotic and Decreased Apoptotic Circulating Endothelial Microparticles is Associated With Improved Prognosis in Patients With Acute Coronary Syndromes

• Published in: Circulation (New York, N.Y.) N.Y.), 2019-11, Vol.140 (Suppl_1 Suppl 1), p.A15899-A15899
• Main Authors: Zacharia, Effimia, Papageorgiou, Nikolaos, Antonopoulos, Alexios S, Oikonomou, Evangelos, Pallantza, Zoi, Miliou, Antigoni, Kriebardis, Anastasios, Nikolaos, Orologas, Valasiadi, Eftychia, Tousoulis, Dimitrios
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.140.suppl_1.15899

IntroductionCirculating apoptotic microparticles (MP) are elevated in acute coronary syndromes (ACS) and have been linked with future adverse cardiovascular events. Preliminary evidence has also shown that non-apoptotic circulating MP exert antithrombotic effects; however, their prognostic significance has not been assessed yet.AimTo explore the prognostic importance of circulating MP profile (apoptotic vs non-apoptotic) in patients with ACS.MethodsWe enrolled 122 patients with ACS49 patients with STEMI, 35 with NSTEMI and 38 with unstable angina (UA). Flow cytometry analysis quantified circulating apoptotic (annexin+) endothelial cell (EMP), red blood cell (RMP) and platelet (PMP)-derived microparticles. To characterize the circulating MP profile, we performed the following categorizationPatients with apoptotic MPsmedian of study group were categorized as having “profile of non-apoptotic MPs”; the rest were categorized as having “profile of apoptotic MPs”. Follow-up duration was 18 months.ResultsPatients with “profile of apoptotic EMP” had a higher incidence of re-hospitalization for cardiovascular causes or death (42.9% vs 20%) and a shorter mean event-free survival (13.2 vs 16.2 months) compared to those with “profile of non-apoptotic” EMP (p=0.019). Importantly, these two groups of patients did not differ in traditional cardiovascular risk factors. For RMP and PMP the findings exhibited the same trend but did not reach the level of statistical significance.ConclusionsThe combination of low apoptotic MPs and high non-apoptotic MPs is associated with improved prognosis in patients with ACS. The apoptotic profile of circulating MP may prove to be a useful tool for risk stratification of these patients.