Abstract 15977: Increased Inflammatory Monocytes in South Asians at Risk for Coronary Atherosclerosis

• Published in: Circulation (New York, N.Y.) N.Y.), 2019-11, Vol.140 (Suppl_1 Suppl 1), p.A15977-A15977
• Main Authors: Ramanathan, Krishnan, Franco, Christopher, Sellers, Stephanie, Whalen, Beth, Selvakumar, Kapilan, Nazzari, Hamed, Kiamanesh, Omid, Rolston, Thomas, Carolyn, Taylor M, Leipsic, Jonathon
• Format: Article
• Language: English
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.140.suppl_1.15977

IntroductionGlobal prevalence of coronary atherosclerosis (CAD) varies with ethnicity. South Asians (SA) have higher rates of cardiovascular morbidity and mortality compared to Caucasians (CA). Inflammation is a central mechanism in atherogenesis and inflammatory monocyte number are an independent predictor of this.HypothesisWe evaluated inflammatory monocyte heterogeneity in a prospectively recruited population of Caucasian and South Asian.MethodsA prospective, consecutively enrolled cohort of patients, ages 19-69, with at least intermediate INTERHEART risk score for CAD were recruited from an outpatient population. Clinical parameters were obtained through history and physical exam findings. Monocyte heterogeneity was analyzed in a fluorescence activated cell scanner using dual color fluorescence (CD14, CD16) within the monocyte gate by trained staff blinded to clinical information. Percentage gated cells were compared using Student’s t-test and clinical data by Chi square test.ResultsThe study cohort comprised of 60 CA and 58 SA patients. The CA group consisted of 36% female with a mean age of 58-y and the SA group was made up of 46% female with a mean age of 54-y. Similar rates of smoking, hypertension, hypercholesterolemia and family history of CAD were seen in SA and CA. The SA patients had increased frequency of a history of diabetes (33% SA vs. 16% CA, P