Waxing and Waning Neuroimaging Abnormalities in Langerhans Cell Histiocytosis

Langerhans cell histiocytosis (LCH) is a rare disease in adults characterized by proliferation of CD1a+/CD207+ and S100 myeloid dendritic cells, forming granulomas.1 An inflammatory exudate is often found with “bean-shaped” nucleated histiocytes. We report a patient with multisystem (liver, lung and...

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Bibliographic Details
Published in:Neurology. Clinical practice 2021-07
Main Authors: McCarron, Luke Vincent, Kelly, Paul, McConville, Conal, Flynn, Peter, McCarron, Mark O.
Format: Article
Language:English
Online Access:Get full text
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Summary:Langerhans cell histiocytosis (LCH) is a rare disease in adults characterized by proliferation of CD1a+/CD207+ and S100 myeloid dendritic cells, forming granulomas.1 An inflammatory exudate is often found with “bean-shaped” nucleated histiocytes. We report a patient with multisystem (liver, lung and brain) LCH in whom neuroimaging abnormalities accumulated and partially regressed prior to definitive treatment.
ISSN:2163-0402
DOI:10.1212/CPJ.0000000000001120