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Postoperative analgesic effect of dexmedetomidine in patients undergoing cardiac surgery
Aim Open heart surgeries are painful procedures that require a large dose of analgesics. The aim of this study was to investigate the effect of postoperative dexmedetomidine (DEX) on the analgesic requirements in postcardiac surgery patients. Settings and design This prospective, randomized, double-...
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| Published in: | Ain-Shams journal of anesthesiology 2017, Vol.10 (1), p.15-19 |
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| Format: | Article |
| Language: | English |
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| container_title | Ain-Shams journal of anesthesiology |
| container_volume | 10 |
| creator | Muharram, Asim A. al-Madani, Ashraf A. H. |
| description | Aim
Open heart surgeries are painful procedures that require a large dose of analgesics.
The aim of this study was to investigate the effect of postoperative
dexmedetomidine (DEX) on the analgesic requirements in postcardiac surgery
patients.
Settings and design
This prospective, randomized, double-blind study was conducted on 60 patients
scheduled for elective coronary artery bypass graft surgery at the Cardiothoracic
Surgery Unit, Ain Shams University Hospital.
Patients and methods
In this study, group D (n=30) received DEX diluted to 4 μg/ml and infused at a rate of
0.1–0.2 μg/kg/h, whereas group C (n=30) received an equal volume of saline at an
infusion rate of 0.1–0.2 μg/kg/h immediately from the end of surgery and
postoperatively in the ICU thereafter. Postoperative analgesia was assessed
using the Numeric Pain Intensity Scale, and sedation was assessed using the
Modified Ramsay Score at T1, T2, T3, T4, T5, and T6 for the first 24 h, as well as
postoperative rescue morphine analgesic requirements.
Statistical analysis
Analysis of data was performed using the Student t-test for independent samples
for parametric data and using the χ2
-tests for categorical data.
Results
There was a significant decrease in the pain scores in group D compared with group
C (P |
| format | article |
| fullrecord | <record><control><sourceid>wolterskluwer_emare</sourceid><recordid>TN_cdi_wolterskluwer_medknow_10_4103_1687-7934_238449_15_Postoper</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10.4103/1687-7934.238449_15_Postoper</sourcerecordid><originalsourceid>FETCH-LOGICAL-e80r-5790dbaa74981adb61319542fc7ec8159b9ed3e469955b6fed784f526df822b03</originalsourceid><addsrcrecordid>eNo9kEtqwzAYhEVpoSHNEQq6gEFPW1qG0BcE2kUW2QnZ-mXUOFKQnLq5fQ1pu5pZDB8zc4MWjGhSaSb3t2hBa9VUjebiHq1K-SSEUCm1qskC7T9SGdMJsh3DF2Ab7dBDCR0G76EbcfLYwfcRHIzpGFyIgEPEpzkNcSz4HB3kPoXY485mF2yHyzn3kC8P6M7bocDqV5do9_y027xW2_eXt816W4EiuZKNJq61thFaUevamnKqpWC-a6BTVOpWg-Mgaq2lbGsPrlHCS1Y7rxhrCV-i9RU7pWGEXA7DeYJs5sKHmCZDiRGUcPP_gGFcCaENleZv-cx4vDLgaDN4a045zO5ilKBMEP4DjKZkHA</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Postoperative analgesic effect of dexmedetomidine in patients undergoing cardiac surgery</title><source>Medknow Open Access Medical Journals</source><creator>Muharram, Asim A. ; al-Madani, Ashraf A. H.</creator><creatorcontrib>Muharram, Asim A. ; al-Madani, Ashraf A. H.</creatorcontrib><description>Aim
Open heart surgeries are painful procedures that require a large dose of analgesics.
The aim of this study was to investigate the effect of postoperative
dexmedetomidine (DEX) on the analgesic requirements in postcardiac surgery
patients.
Settings and design
This prospective, randomized, double-blind study was conducted on 60 patients
scheduled for elective coronary artery bypass graft surgery at the Cardiothoracic
Surgery Unit, Ain Shams University Hospital.
Patients and methods
In this study, group D (n=30) received DEX diluted to 4 μg/ml and infused at a rate of
0.1–0.2 μg/kg/h, whereas group C (n=30) received an equal volume of saline at an
infusion rate of 0.1–0.2 μg/kg/h immediately from the end of surgery and
postoperatively in the ICU thereafter. Postoperative analgesia was assessed
using the Numeric Pain Intensity Scale, and sedation was assessed using the
Modified Ramsay Score at T1, T2, T3, T4, T5, and T6 for the first 24 h, as well as
postoperative rescue morphine analgesic requirements.
Statistical analysis
Analysis of data was performed using the Student t-test for independent samples
for parametric data and using the χ2
-tests for categorical data.
Results
There was a significant decrease in the pain scores in group D compared with group
C (P<0.001). Morphine rescue analgesia was needed in 10% of patients in group D
and in 95% of patients in group C, with a significant reduction in time to extubation
and ICU length of stay in group D. The incidence of postoperative nausea and
vomiting was lower in group D compared with group C but did not reach statistical
significance.
Conclusion
Adding DEX after coronary artery bypass graft decreased both postoperative
analgesic requirement and pain score without hemodynamic effects.</description><identifier>ISSN: 1687-7934</identifier><identifier>EISSN: 2090-925X</identifier><language>eng</language><publisher>Cairo, Egypt: Ain Shams University, Faculty of Medicine, Department of Anesthesiology</publisher><ispartof>Ain-Shams journal of anesthesiology, 2017, Vol.10 (1), p.15-19</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.asja.eg.net/images/cover.png</thumbnail><link.rule.ids>314,776,780,27435</link.rule.ids></links><search><creatorcontrib>Muharram, Asim A.</creatorcontrib><creatorcontrib>al-Madani, Ashraf A. H.</creatorcontrib><title>Postoperative analgesic effect of dexmedetomidine in patients undergoing cardiac surgery</title><title>Ain-Shams journal of anesthesiology</title><description>Aim
Open heart surgeries are painful procedures that require a large dose of analgesics.
The aim of this study was to investigate the effect of postoperative
dexmedetomidine (DEX) on the analgesic requirements in postcardiac surgery
patients.
Settings and design
This prospective, randomized, double-blind study was conducted on 60 patients
scheduled for elective coronary artery bypass graft surgery at the Cardiothoracic
Surgery Unit, Ain Shams University Hospital.
Patients and methods
In this study, group D (n=30) received DEX diluted to 4 μg/ml and infused at a rate of
0.1–0.2 μg/kg/h, whereas group C (n=30) received an equal volume of saline at an
infusion rate of 0.1–0.2 μg/kg/h immediately from the end of surgery and
postoperatively in the ICU thereafter. Postoperative analgesia was assessed
using the Numeric Pain Intensity Scale, and sedation was assessed using the
Modified Ramsay Score at T1, T2, T3, T4, T5, and T6 for the first 24 h, as well as
postoperative rescue morphine analgesic requirements.
Statistical analysis
Analysis of data was performed using the Student t-test for independent samples
for parametric data and using the χ2
-tests for categorical data.
Results
There was a significant decrease in the pain scores in group D compared with group
C (P<0.001). Morphine rescue analgesia was needed in 10% of patients in group D
and in 95% of patients in group C, with a significant reduction in time to extubation
and ICU length of stay in group D. The incidence of postoperative nausea and
vomiting was lower in group D compared with group C but did not reach statistical
significance.
Conclusion
Adding DEX after coronary artery bypass graft decreased both postoperative
analgesic requirement and pain score without hemodynamic effects.</description><issn>1687-7934</issn><issn>2090-925X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNo9kEtqwzAYhEVpoSHNEQq6gEFPW1qG0BcE2kUW2QnZ-mXUOFKQnLq5fQ1pu5pZDB8zc4MWjGhSaSb3t2hBa9VUjebiHq1K-SSEUCm1qskC7T9SGdMJsh3DF2Ab7dBDCR0G76EbcfLYwfcRHIzpGFyIgEPEpzkNcSz4HB3kPoXY485mF2yHyzn3kC8P6M7bocDqV5do9_y027xW2_eXt816W4EiuZKNJq61thFaUevamnKqpWC-a6BTVOpWg-Mgaq2lbGsPrlHCS1Y7rxhrCV-i9RU7pWGEXA7DeYJs5sKHmCZDiRGUcPP_gGFcCaENleZv-cx4vDLgaDN4a045zO5ilKBMEP4DjKZkHA</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Muharram, Asim A.</creator><creator>al-Madani, Ashraf A. H.</creator><general>Ain Shams University, Faculty of Medicine, Department of Anesthesiology</general><general>Wolters Kluwer India Pvt. Ltd</general><scope>ADJCN</scope><scope>AHFXO</scope></search><sort><creationdate>2017</creationdate><title>Postoperative analgesic effect of dexmedetomidine in patients undergoing cardiac surgery</title><author>Muharram, Asim A. ; al-Madani, Ashraf A. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e80r-5790dbaa74981adb61319542fc7ec8159b9ed3e469955b6fed784f526df822b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muharram, Asim A.</creatorcontrib><creatorcontrib>al-Madani, Ashraf A. H.</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><jtitle>Ain-Shams journal of anesthesiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muharram, Asim A.</au><au>al-Madani, Ashraf A. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postoperative analgesic effect of dexmedetomidine in patients undergoing cardiac surgery</atitle><jtitle>Ain-Shams journal of anesthesiology</jtitle><date>2017</date><risdate>2017</risdate><volume>10</volume><issue>1</issue><spage>15</spage><epage>19</epage><pages>15-19</pages><issn>1687-7934</issn><eissn>2090-925X</eissn><abstract>Aim
Open heart surgeries are painful procedures that require a large dose of analgesics.
The aim of this study was to investigate the effect of postoperative
dexmedetomidine (DEX) on the analgesic requirements in postcardiac surgery
patients.
Settings and design
This prospective, randomized, double-blind study was conducted on 60 patients
scheduled for elective coronary artery bypass graft surgery at the Cardiothoracic
Surgery Unit, Ain Shams University Hospital.
Patients and methods
In this study, group D (n=30) received DEX diluted to 4 μg/ml and infused at a rate of
0.1–0.2 μg/kg/h, whereas group C (n=30) received an equal volume of saline at an
infusion rate of 0.1–0.2 μg/kg/h immediately from the end of surgery and
postoperatively in the ICU thereafter. Postoperative analgesia was assessed
using the Numeric Pain Intensity Scale, and sedation was assessed using the
Modified Ramsay Score at T1, T2, T3, T4, T5, and T6 for the first 24 h, as well as
postoperative rescue morphine analgesic requirements.
Statistical analysis
Analysis of data was performed using the Student t-test for independent samples
for parametric data and using the χ2
-tests for categorical data.
Results
There was a significant decrease in the pain scores in group D compared with group
C (P<0.001). Morphine rescue analgesia was needed in 10% of patients in group D
and in 95% of patients in group C, with a significant reduction in time to extubation
and ICU length of stay in group D. The incidence of postoperative nausea and
vomiting was lower in group D compared with group C but did not reach statistical
significance.
Conclusion
Adding DEX after coronary artery bypass graft decreased both postoperative
analgesic requirement and pain score without hemodynamic effects.</abstract><cop>Cairo, Egypt</cop><pub>Ain Shams University, Faculty of Medicine, Department of Anesthesiology</pub><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Medknow Open Access Medical Journals |
| title | Postoperative analgesic effect of dexmedetomidine in patients undergoing cardiac surgery |
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