82 : Does Apoptotic Body Impair Pregnancy Outcome

Background: Morphologically suboptimal blastocyst is often associated with poorer pregnancy outcomes. Apoptotic body is one of the abnormal findings in blastocysts characterised by cellular shrinkage and a darker appearance. The presence of apoptotic bodies may be suggestive of ongoing cellular dege...

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Bibliographic Details
Published in:Fertility & reproduction 2023-12, Vol.5 (4), p.687-688
Main Authors: Rosli, Nur Ilanah, Khir, Najwa Safuhah Mohamad, Khalid, Nurul Izzah Ab, Kadir, Nursyuhada Akma Abdul, Zain, Murizah Mohd
Format: Article
Language:English
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POSTER PRESENTATION: ART, Laboratory
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Summary:Background: Morphologically suboptimal blastocyst is often associated with poorer pregnancy outcomes. Apoptotic body is one of the abnormal findings in blastocysts characterised by cellular shrinkage and a darker appearance. The presence of apoptotic bodies may be suggestive of ongoing cellular degeneration. Cellular degeneration in the blastocyst is part of its self-corrective mechanism. The degenerated cells will deplete through the phagocytosis process. Aims: This is a retrospective study that aims to analyse whether the presence of apoptotic body has a significant impact on pregnancy outcomes. Method: We compare the outcome of the frozen-thawed embryo transfer (FET) cycle of blastocysts with apoptotic body and without it as a control. We further divide the cases into single blastocyst transfer and double blastocyst transfer. The data was collected from Vistana Fertility Centre from January to December 2022. Results: Conclusion: Data analysis showed that there is no significant difference between the study group and the control group. Hence, the presence of dead cells did not negatively impact the pregnancy outcomes.
ISSN:2661-3182
2661-3174
DOI:10.1142/S266131822374403X