Human tolerogenic dendritic cells regulate immune responses through lactate synthesis

Cell therapy is a promising strategy for treating patients suffering from autoimmune or inflammatory diseases or receiving a transplant. Based on our preclinical studies, we have generated human autologous tolerogenic dendritic cells (ATDCs), which are being tested in a first-in-man clinical trial i...

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Main Authors: Eros Marin, Laurence Bouchet-Delbos, Ophélie Renoult, Cédric Louvet, Véronique Nerriere-Daguin, Amy Managh, Amandine Even, Matthieu Giraud, Thien Phong Vu Manh, Audrey Aguesse, Gaelle Bériou, Elise Chiffoleau, Brigitte Alliot-Licht, Xavier Prieur, Mikael Croyal, James A Hutchinson, Natasa Obermajer, Edward K Geissler, Bernard Vanhove, Gilles Blancho, Marc Dalod, Régis Josien, Claire Pecqueur, Maria-Cristina Cuturi, Aurélie Moreau
Format: Default Article
Published: 2019
Subjects:
Lactate
Immunometabolism
Tolerance induction
Tolerogenic dendritic cells
Cell therapy in humans
Online Access:https://hdl.handle.net/2134/11310755.v1
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https://hdl.handle.net/2134/11310755.v1

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