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Severely restricting energy intake for 24 h does not affect markers of bone metabolism at rest or in response to re-feeding
© 2020, The Author(s). Purpose: Intermittent energy restriction commonly refers to ad libitum energy intake punctuated with 24 h periods of severe energy restriction. This can improve markers of metabolic health but the effects on bone metabolism are unknown. This study assessed how 24 h severe ener...
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| Format: | Default Article |
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2020
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| Online Access: | https://hdl.handle.net/2134/11871759.v1 |
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| _version_ | 1818167051263410176 |
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| author | David Clayton Lewis James Craig Sale Iain Templeman James A. Betts Ian Varley |
| author_facet | David Clayton Lewis James Craig Sale Iain Templeman James A. Betts Ian Varley |
| author_sort | David Clayton (1258170) |
| collection | Figshare |
| description | © 2020, The Author(s). Purpose: Intermittent energy restriction commonly refers to ad libitum energy intake punctuated with 24 h periods of severe energy restriction. This can improve markers of metabolic health but the effects on bone metabolism are unknown. This study assessed how 24 h severe energy restriction and subsequent refeeding affected markers of bone turnover. Methods: In a randomised order, 16 lean men and women completed 2, 48 h trials over 3 days. On day 1, participants consumed a 24 h diet providing 100% [EB: 9.27 (1.43) MJ] or 25% [ER: 2.33 (0.34) MJ] of estimated energy requirements. On day 2, participants consumed a standardised breakfast (08:00), followed by an ad libitum lunch (12:00) and dinner (19:30). Participants then fasted overnight, returning on day 3. Plasma concentrations of C-terminal telopeptide of type I collagen (CTX), procollagen type 1 N-terminal propeptide (P1NP) and parathyroid hormone (PTH) were assessed as indices of bone metabolism after an overnight fast on days 1–3, and for 4 h after breakfast on day 2. Results: There were no differences between trials in fasting concentrations of CTX, P1NP or PTH on days 1–3 (P > 0.512). During both trials, consuming breakfast reduced CTX between 1 and 4 h (P < 0.001) and PTH between 1 and 2 h (P < 0.05), but did not affect P1NP (P = 0.773) Postprandial responses for CTX (P = 0.157), P1NP (P = 0.148) and PTH (P = 0.575) were not different between trials. Ad libitum energy intake on day 2 was greater on ER [12.62 (2.46) MJ] than EB [11.91 (2.49) MJ]. Conclusions: Twenty-four hour severe energy restriction does not affect markers of bone metabolism. |
| format | Default Article |
| id | rr-article-11871759 |
| institution | Loughborough University |
| publishDate | 2020 |
| record_format | Figshare |
| spelling | rr-article-118717592020-02-03T00:00:00Z Severely restricting energy intake for 24 h does not affect markers of bone metabolism at rest or in response to re-feeding David Clayton (1258170) Lewis James (1249500) Craig Sale (1259799) Iain Templeman (4819074) James A. Betts (3218589) Ian Varley (566584) Bone Bone metabolism Intermittent energy restriction Intermittent fasting Weight management Nutrition & Dietetics Nutrition and Dietetics © 2020, The Author(s). Purpose: Intermittent energy restriction commonly refers to ad libitum energy intake punctuated with 24 h periods of severe energy restriction. This can improve markers of metabolic health but the effects on bone metabolism are unknown. This study assessed how 24 h severe energy restriction and subsequent refeeding affected markers of bone turnover. Methods: In a randomised order, 16 lean men and women completed 2, 48 h trials over 3 days. On day 1, participants consumed a 24 h diet providing 100% [EB: 9.27 (1.43) MJ] or 25% [ER: 2.33 (0.34) MJ] of estimated energy requirements. On day 2, participants consumed a standardised breakfast (08:00), followed by an ad libitum lunch (12:00) and dinner (19:30). Participants then fasted overnight, returning on day 3. Plasma concentrations of C-terminal telopeptide of type I collagen (CTX), procollagen type 1 N-terminal propeptide (P1NP) and parathyroid hormone (PTH) were assessed as indices of bone metabolism after an overnight fast on days 1–3, and for 4 h after breakfast on day 2. Results: There were no differences between trials in fasting concentrations of CTX, P1NP or PTH on days 1–3 (P > 0.512). During both trials, consuming breakfast reduced CTX between 1 and 4 h (P < 0.001) and PTH between 1 and 2 h (P < 0.05), but did not affect P1NP (P = 0.773) Postprandial responses for CTX (P = 0.157), P1NP (P = 0.148) and PTH (P = 0.575) were not different between trials. Ad libitum energy intake on day 2 was greater on ER [12.62 (2.46) MJ] than EB [11.91 (2.49) MJ]. Conclusions: Twenty-four hour severe energy restriction does not affect markers of bone metabolism. 2020-02-03T00:00:00Z Text Journal contribution 2134/11871759.v1 https://figshare.com/articles/journal_contribution/Severely_restricting_energy_intake_for_24_h_does_not_affect_markers_of_bone_metabolism_at_rest_or_in_response_to_re-feeding/11871759 CC BY 4.0 |
| spellingShingle | Bone Bone metabolism Intermittent energy restriction Intermittent fasting Weight management Nutrition & Dietetics Nutrition and Dietetics David Clayton Lewis James Craig Sale Iain Templeman James A. Betts Ian Varley Severely restricting energy intake for 24 h does not affect markers of bone metabolism at rest or in response to re-feeding |
| title | Severely restricting energy intake for 24 h does not affect markers of bone metabolism at rest or in response to re-feeding |
| title_full | Severely restricting energy intake for 24 h does not affect markers of bone metabolism at rest or in response to re-feeding |
| title_fullStr | Severely restricting energy intake for 24 h does not affect markers of bone metabolism at rest or in response to re-feeding |
| title_full_unstemmed | Severely restricting energy intake for 24 h does not affect markers of bone metabolism at rest or in response to re-feeding |
| title_short | Severely restricting energy intake for 24 h does not affect markers of bone metabolism at rest or in response to re-feeding |
| title_sort | severely restricting energy intake for 24 h does not affect markers of bone metabolism at rest or in response to re-feeding |
| topic | Bone Bone metabolism Intermittent energy restriction Intermittent fasting Weight management Nutrition & Dietetics Nutrition and Dietetics |
| url | https://hdl.handle.net/2134/11871759.v1 |