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Cancer-associated fibroblasts in undifferentiated nasopharyngeal carcinoma: a putative role for the EBV-encoded oncoprotein, LMP1
Undifferentiated nasopharyngeal carcinoma (NPC) is 100% associated with Epstein–Barr virus (EBV) infection, and biopsies display variable levels of expression of the viral oncoprotein, latent membrane protein 1 (LMP1). Emerging evidence suggests an important role for cancer-associated fibroblasts (C...
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| Format: | Default Article |
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2019
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| Online Access: | https://hdl.handle.net/2134/11920785.v1 |
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| _version_ | 1818167702635675648 |
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| author | Mhairi Morris |
| author_facet | Mhairi Morris |
| author_sort | Mhairi Morris (3718882) |
| collection | Figshare |
| description | Undifferentiated nasopharyngeal carcinoma (NPC) is 100% associated with Epstein–Barr virus (EBV) infection, and biopsies display variable levels of expression of the viral oncoprotein, latent membrane protein 1 (LMP1). Emerging evidence suggests an important role for cancer-associated fibroblasts (CAFs) in the NPC tumour microenvironment, yet the interaction between the virus, its latent gene products and the recruitment and activation of CAFs in the NPC tumour stroma remains unclear. This short review will discuss the current evidence for the importance of CAFs in NPC pathogenesis and outline a putative role for the EBV-encoded oncoprotein, LMP1, in governing tumour–stromal interactions. |
| format | Default Article |
| id | rr-article-11920785 |
| institution | Loughborough University |
| publishDate | 2019 |
| record_format | Figshare |
| spelling | rr-article-119207852019-12-20T00:00:00Z Cancer-associated fibroblasts in undifferentiated nasopharyngeal carcinoma: a putative role for the EBV-encoded oncoprotein, LMP1 Mhairi Morris (3718882) EBV LMP1 NPC fibroblast myofibroblast cancer-associated fibroblasts tumour microenvironment tumour stroma Undifferentiated nasopharyngeal carcinoma (NPC) is 100% associated with Epstein–Barr virus (EBV) infection, and biopsies display variable levels of expression of the viral oncoprotein, latent membrane protein 1 (LMP1). Emerging evidence suggests an important role for cancer-associated fibroblasts (CAFs) in the NPC tumour microenvironment, yet the interaction between the virus, its latent gene products and the recruitment and activation of CAFs in the NPC tumour stroma remains unclear. This short review will discuss the current evidence for the importance of CAFs in NPC pathogenesis and outline a putative role for the EBV-encoded oncoprotein, LMP1, in governing tumour–stromal interactions. 2019-12-20T00:00:00Z Text Journal contribution 2134/11920785.v1 https://figshare.com/articles/journal_contribution/Cancer-associated_fibroblasts_in_undifferentiated_nasopharyngeal_carcinoma_a_putative_role_for_the_EBV-encoded_oncoprotein_LMP1/11920785 CC BY 4.0 |
| spellingShingle | EBV LMP1 NPC fibroblast myofibroblast cancer-associated fibroblasts tumour microenvironment tumour stroma Mhairi Morris Cancer-associated fibroblasts in undifferentiated nasopharyngeal carcinoma: a putative role for the EBV-encoded oncoprotein, LMP1 |
| title | Cancer-associated fibroblasts in undifferentiated nasopharyngeal carcinoma: a putative role for the EBV-encoded oncoprotein, LMP1 |
| title_full | Cancer-associated fibroblasts in undifferentiated nasopharyngeal carcinoma: a putative role for the EBV-encoded oncoprotein, LMP1 |
| title_fullStr | Cancer-associated fibroblasts in undifferentiated nasopharyngeal carcinoma: a putative role for the EBV-encoded oncoprotein, LMP1 |
| title_full_unstemmed | Cancer-associated fibroblasts in undifferentiated nasopharyngeal carcinoma: a putative role for the EBV-encoded oncoprotein, LMP1 |
| title_short | Cancer-associated fibroblasts in undifferentiated nasopharyngeal carcinoma: a putative role for the EBV-encoded oncoprotein, LMP1 |
| title_sort | cancer-associated fibroblasts in undifferentiated nasopharyngeal carcinoma: a putative role for the ebv-encoded oncoprotein, lmp1 |
| topic | EBV LMP1 NPC fibroblast myofibroblast cancer-associated fibroblasts tumour microenvironment tumour stroma |
| url | https://hdl.handle.net/2134/11920785.v1 |