Design, synthesis, radiosynthesis and biological evaluation of fenretinide analogues as anticancer and metabolic syndrome‐preventive agents

Fenretinide (4-HPR) is a synthetic derivative of all-trans-retinoic acid (ATRA) characterised by improved therapeutic properties and toxicological profile relative to ATRA. 4-HPR has been mostly investigated as an anti-cancer agent, but recent studies showed its promising therapeutic potential for p...

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Bibliographic Details
Main Authors: Ilaria Patruno, Dawn Thompson, Sergio Dall'Angelo, Albert D Windhorst, Danielle J Vugts, Alex J Poot, Nimesh Mody, Matteo Zanda
Format: Default Article
Published: 2020
Subjects:
Organic chemistry not elsewhere classified
cancer
drug discovery
fenretinide
metabolic syndrome
radiopharmaceuticals
Organic Chemistry
Online Access:https://hdl.handle.net/2134/12675104.v1
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https://hdl.handle.net/2134/12675104.v1

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