A synthetic diterpene analogue inhibits mycobacterial persistence and biofilm formation by targeting (p)ppGpp synthetases

Bacterial persistence coupled with biofilm formation is directly associated with failure of antibiotic treatment of TB. We have now identified 4-(4,7-DiMethyl-1,2,3,4-tetrahydroNaphthalene-1-yl)Pentanoic acid (DMNP), a synthetic diterpene analogue, as a lead compound that was capable of suppressing...

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Bibliographic Details
Main Authors: Alexaner G Tkachenko, Natalya Kashevarova, Roman Sidorov, Larisa Nesterova, Anna Akhova, Ivan Tsyganov, Vladimir Vaganov, Sergei Shipilovskikh, Aleksandr Rubtsov, Andrei Malkov
Format: Default Article
Published: 2021
Subjects:
diterpene
synthetic analogue
mycobacteria
persistence
biofilm formation
target
RelMsm
RelZ
(p)ppGpp synthetases
Online Access:https://hdl.handle.net/2134/13640669.v1
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https://hdl.handle.net/2134/13640669.v1

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