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The effect of creatine supplementation on markers of exercise-induced muscle damage: A systematic review and meta-analysis of human intervention trials
This systematic review and meta-analysis examined the effects of creatine supplementation on recovery from exercise-induced muscle damage, and is reported according to the PRISMA guidelines. MEDLINE and SPORTDiscus were searched for articles from inception until April 2020. Inclusion criteria were a...
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| Format: | Default Article |
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2021
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| Online Access: | https://hdl.handle.net/2134/14113436.v1 |
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| _version_ | 1818166914771320832 |
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| author | Bethany Northeast Tom Clifford |
| author_facet | Bethany Northeast Tom Clifford |
| author_sort | Bethany Northeast (10194479) |
| collection | Figshare |
| description | This systematic review and meta-analysis examined the effects of creatine supplementation on recovery from exercise-induced muscle damage, and is reported according to the PRISMA guidelines. MEDLINE and SPORTDiscus were searched for articles from inception until April 2020. Inclusion criteria were adult participants (≥18 years); creatine provided before and/or after exercise versus a noncreatine comparator; measurement of muscle function recovery, muscle soreness, inflammation, myocellular protein efflux, oxidative stress; range of motion; randomized controlled trials in humans. Thirteen studies (totaling 278 participants; 235 males and 43 females; age range 20–60 years) were deemed eligible for analysis. Data extraction was performed independently by both authors. The Cochrane Collaboration Risk of Bias Tool was used to critically appraise the studies; forest plots were generated with random-effects model and standardized mean differences. Creatine supplementation did not alter muscle strength, muscle soreness, range of motion, or inflammation at each of the five follow-up times after exercise ( .05). Creatine attenuated creatine kinase activity at 48-hr postexercise (standardized mean difference: −1.06; 95% confidence interval [−1.97, −0.14]; p = .02) but at no other time points. High (I2; >75%) and significant (Chi2; p |
| format | Default Article |
| id | rr-article-14113436 |
| institution | Loughborough University |
| publishDate | 2021 |
| record_format | Figshare |
| spelling | rr-article-141134362021-05-31T00:00:00Z The effect of creatine supplementation on markers of exercise-induced muscle damage: A systematic review and meta-analysis of human intervention trials Bethany Northeast (10194479) Tom Clifford (7468394) Sport Sciences Human Movement and Sports Sciences Medical Physiology phosphocreatine oxidative stress nutrition exercise recovery antioxidants This systematic review and meta-analysis examined the effects of creatine supplementation on recovery from exercise-induced muscle damage, and is reported according to the PRISMA guidelines. MEDLINE and SPORTDiscus were searched for articles from inception until April 2020. Inclusion criteria were adult participants (≥18 years); creatine provided before and/or after exercise versus a noncreatine comparator; measurement of muscle function recovery, muscle soreness, inflammation, myocellular protein efflux, oxidative stress; range of motion; randomized controlled trials in humans. Thirteen studies (totaling 278 participants; 235 males and 43 females; age range 20–60 years) were deemed eligible for analysis. Data extraction was performed independently by both authors. The Cochrane Collaboration Risk of Bias Tool was used to critically appraise the studies; forest plots were generated with random-effects model and standardized mean differences. Creatine supplementation did not alter muscle strength, muscle soreness, range of motion, or inflammation at each of the five follow-up times after exercise (<30 min, 24, 48, 72, and 96 hr; p > .05). Creatine attenuated creatine kinase activity at 48-hr postexercise (standardized mean difference: −1.06; 95% confidence interval [−1.97, −0.14]; p = .02) but at no other time points. High (I2; >75%) and significant (Chi2; p < .01) heterogeneity was identified for all outcome measures at various follow-up times. In conclusion, creatine supplementation does not accelerate recovery following exercise-induced muscle damage; however, well-controlled studies with higher sample sizes are warranted to verify these conclusions. Systematic review registration (PROSPERO CRD42020178735). 2021-05-31T00:00:00Z Text Journal contribution 2134/14113436.v1 https://figshare.com/articles/journal_contribution/The_effect_of_creatine_supplementation_on_markers_of_exercise-induced_muscle_damage_A_systematic_review_and_meta-analysis_of_human_intervention_trials/14113436 CC BY-NC-ND 4.0 |
| spellingShingle | Sport Sciences Human Movement and Sports Sciences Medical Physiology phosphocreatine oxidative stress nutrition exercise recovery antioxidants Bethany Northeast Tom Clifford The effect of creatine supplementation on markers of exercise-induced muscle damage: A systematic review and meta-analysis of human intervention trials |
| title | The effect of creatine supplementation on markers of exercise-induced muscle damage: A systematic review and meta-analysis of human intervention trials |
| title_full | The effect of creatine supplementation on markers of exercise-induced muscle damage: A systematic review and meta-analysis of human intervention trials |
| title_fullStr | The effect of creatine supplementation on markers of exercise-induced muscle damage: A systematic review and meta-analysis of human intervention trials |
| title_full_unstemmed | The effect of creatine supplementation on markers of exercise-induced muscle damage: A systematic review and meta-analysis of human intervention trials |
| title_short | The effect of creatine supplementation on markers of exercise-induced muscle damage: A systematic review and meta-analysis of human intervention trials |
| title_sort | effect of creatine supplementation on markers of exercise-induced muscle damage: a systematic review and meta-analysis of human intervention trials |
| topic | Sport Sciences Human Movement and Sports Sciences Medical Physiology phosphocreatine oxidative stress nutrition exercise recovery antioxidants |
| url | https://hdl.handle.net/2134/14113436.v1 |