Ligand-selective small molecule modulators of the constitutively active vGPCR US28

US28 is a broad-spectrum constitutively active G protein-coupled receptor encoded by the human cytomegalovirus (HCMV). It binds and scavenges multiple CC-chemokines as well as CX3CL1 (fractalkine) by constitutive receptor endocytosis to escape immune surveillance. We herein report the design and cha...

Full description

Bibliographic Details

Main Authors:	Roxana-Maria Amărandi, Michael Lückmann, Motiejus Melynis, Mette H Jakobsen, Zohreh Fallah, Katja Spiess, Gertrud M Hjortø, Aurel Pui, Thomas M Frimurer, Mette M Rosenkilde
Format:	Default Article
Published:	2018
Subjects:	Organic chemistry not elsewhere classified Medicinal & Biomolecular Chemistry Medicinal and Biomolecular Chemistry Pharmacology and Pharmaceutical Sciences Molecular modeling Virtual screening G protein-coupled receptor Drug discovery Organic Chemistry
Online Access:	https://hdl.handle.net/2134/14307758.v1
Tags:	Add Tag No Tags, Be the first to tag this record!