Localising individual atoms of tryptophan side chains in the metallo-<i>β</i>-lactamase IMP-1 by pseudocontact shifts from paramagnetic lanthanoid tags at multiple sites

The metallo-β-lactamase IMP-1 features a flexible loop near the active site that assumes different conformations in single crystal structures, which may assist in substrate binding and enzymatic activity. To probe the position of this loop, we labelled the tryptophan residues of IMP-1 with 7-13C-ind...

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Bibliographic Details
Main Authors: Henry W Orton, Iresha D Herath, Ansis Maleckis, Shereen Jabar, Monika Szabo, Bim Graham, Colum Breen, Lydia Topping, Stephen Butler, Gottfried Otting
Format: Default Article
Published: 2022
Subjects:
Chemistry
Online Access:https://hdl.handle.net/2134/19329350.v1
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https://hdl.handle.net/2134/19329350.v1

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