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Ageing modifies acute resting blood pressure responses to incremental consumption of dietary nitrate: a randomised, cross-over clinical trial
Beetroot is a rich source of nitrate (NO3-) that has been shown to reduce blood pressure (BP). Yet, no studies have examined the vascular benefits of beetroot in whole-food form and whether the effects are modified by age. This study was a four-arm, randomised, open-label, crossover design in 24 hea...
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| Main Authors: | , , , , , , |
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| Format: | Default Article |
| Published: |
2022
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| Subjects: | |
| Online Access: | https://hdl.handle.net/2134/19739332.v1 |
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| Summary: | Beetroot is a rich source of nitrate (NO3-) that has been shown to reduce blood pressure (BP). Yet, no studies have examined the vascular benefits of beetroot in whole-food form and whether the effects are modified by age. This study was a four-arm, randomised, open-label, crossover design in 24 healthy adults (young n=12, age 27±4 years, old n=12, age 64±5 years). Participants consumed whole cooked beetroot at portions of (NO3- content in brackets) 100 (272mg), 200 (544mg) and 300g (816mg), and a 200ml solution containing 1000mg of potassium nitrate (KNO3) on 4 separate occasions over a 4-week period (≥7-day washout period). BP, plasma NO3- and nitrite (NO2-) concentrations, and post-occlusion reactive hyperaemia (PORH) via laser Doppler, were measured pre and up to 5 hours post-intervention. Data were analysed by repeated measures analysis of variance. Plasma NO2- concentrations were higher in the young vs. old at baseline and post-intervention (P |
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