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Ageing modifies acute resting blood pressure responses to incremental consumption of dietary nitrate: a randomised, cross-over clinical trial
Beetroot is a rich source of nitrate (NO3-) that has been shown to reduce blood pressure (BP). Yet, no studies have examined the vascular benefits of beetroot in whole-food form and whether the effects are modified by age. This study was a four-arm, randomised, open-label, crossover design in 24 hea...
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| Format: | Default Article |
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2022
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| Online Access: | https://hdl.handle.net/2134/19739332.v1 |
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| _version_ | 1818165992308604928 |
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| author | Tess Capper Tom Clifford Guy Taylor Wasim Iqbal Daniel West Emma Stevenson Mario Siervo |
| author_facet | Tess Capper Tom Clifford Guy Taylor Wasim Iqbal Daniel West Emma Stevenson Mario Siervo |
| author_sort | Tess Capper (5058563) |
| collection | Figshare |
| description | Beetroot is a rich source of nitrate (NO3-) that has been shown to reduce blood pressure (BP). Yet, no studies have examined the vascular benefits of beetroot in whole-food form and whether the effects are modified by age. This study was a four-arm, randomised, open-label, crossover design in 24 healthy adults (young n=12, age 27±4 years, old n=12, age 64±5 years). Participants consumed whole cooked beetroot at portions of (NO3- content in brackets) 100 (272mg), 200 (544mg) and 300g (816mg), and a 200ml solution containing 1000mg of potassium nitrate (KNO3) on 4 separate occasions over a 4-week period (≥7-day washout period). BP, plasma NO3- and nitrite (NO2-) concentrations, and post-occlusion reactive hyperaemia (PORH) via laser Doppler, were measured pre and up to 5 hours post-intervention. Data were analysed by repeated measures analysis of variance. Plasma NO2- concentrations were higher in the young vs. old at baseline and post-intervention (P |
| format | Default Article |
| id | rr-article-19739332 |
| institution | Loughborough University |
| publishDate | 2022 |
| record_format | Figshare |
| spelling | rr-article-197393322022-05-05T00:00:00Z Ageing modifies acute resting blood pressure responses to incremental consumption of dietary nitrate: a randomised, cross-over clinical trial Tess Capper (5058563) Tom Clifford (7468394) Guy Taylor (7408826) Wasim Iqbal (12528880) Daniel West (2308690) Emma Stevenson (649191) Mario Siervo (359964) beetroot cardiovascular disease vascular health ageing vegetables nitric oxide <p>Beetroot is a rich source of nitrate (NO<sub>3-</sub>) that has been shown to reduce blood pressure (BP). Yet, no studies have examined the vascular benefits of beetroot in whole-food form and whether the effects are modified by age. This study was a four-arm, randomised, open-label, crossover design in 24 healthy adults (young n=12, age 27±4 years, old n=12, age 64±5 years). Participants consumed whole cooked beetroot at portions of (NO<sub>3-</sub> content in brackets) 100 (272mg), 200 (544mg) and 300g (816mg), and a 200ml solution containing 1000mg of potassium nitrate (KNO<sub>3</sub>) on 4 separate occasions over a 4-week period (≥7-day washout period). BP, plasma NO<sub>3-</sub> and nitrite (NO<sub>2-</sub>) concentrations, and post-occlusion reactive hyperaemia (PORH) via laser Doppler, were measured pre and up to 5 hours post-intervention. Data were analysed by repeated measures analysis of variance. Plasma NO<sub>2-</sub> concentrations were higher in the young vs. old at baseline and post-intervention (P<0.05). All NO<sub>3-</sub> interventions decreased systolic and diastolic BP in young participants (P<0.05) whereas only KNO<sub>3</sub> (at 240-300 min post-intake) significantly decreased systolic (-4.8 mmHg, -3.5%, P=0.024) and diastolic (-5.4 mmHg, -6.5%, P=0.007) BP in older participants. In conclusion, incremental doses of dietary NO<sub>3-</sub> reduced systolic and diastolic BP in healthy young adults whereas in the older group a significant decrease was only observed with the highest dose. The lower plasma NO<sub>2-</sub> concentrations in older participants suggests there may be mechanistic differences in the production of NO from dietary NO<sub>3-</sub> in young and older populations.</p> 2022-05-05T00:00:00Z Text Journal contribution 2134/19739332.v1 https://figshare.com/articles/journal_contribution/Ageing_modifies_acute_resting_blood_pressure_responses_to_incremental_consumption_of_dietary_nitrate_a_randomised_cross-over_clinical_trial/19739332 CC BY-NC-ND 4.0 |
| spellingShingle | beetroot cardiovascular disease vascular health ageing vegetables nitric oxide Tess Capper Tom Clifford Guy Taylor Wasim Iqbal Daniel West Emma Stevenson Mario Siervo Ageing modifies acute resting blood pressure responses to incremental consumption of dietary nitrate: a randomised, cross-over clinical trial |
| title | Ageing modifies acute resting blood pressure responses to incremental consumption of dietary nitrate: a randomised, cross-over clinical trial |
| title_full | Ageing modifies acute resting blood pressure responses to incremental consumption of dietary nitrate: a randomised, cross-over clinical trial |
| title_fullStr | Ageing modifies acute resting blood pressure responses to incremental consumption of dietary nitrate: a randomised, cross-over clinical trial |
| title_full_unstemmed | Ageing modifies acute resting blood pressure responses to incremental consumption of dietary nitrate: a randomised, cross-over clinical trial |
| title_short | Ageing modifies acute resting blood pressure responses to incremental consumption of dietary nitrate: a randomised, cross-over clinical trial |
| title_sort | ageing modifies acute resting blood pressure responses to incremental consumption of dietary nitrate: a randomised, cross-over clinical trial |
| topic | beetroot cardiovascular disease vascular health ageing vegetables nitric oxide |
| url | https://hdl.handle.net/2134/19739332.v1 |