Monodispersed sirolimus-loaded PLGA microspheres with a controlled degree of drug-polymer phase separation for drug-coated implantable medical devices and subcutaneous injection

Monodispersed sirolimus (SRL)-loaded poly(lactic-co-glycolic acid) (PLGA) microspheres with a diameter of 1.8, 3.8 and 8.5 μm were produced by high-throughput microfluidic step emulsification - solvent evaporation using single crystal silicon chips consisted of 540-1710 terraced microchannels with a...

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Bibliographic Details

Main Authors:	Zilin Zhang, Ekanem Ekanem, Mitsutoshi Nakajima, Guido Bolognesi, Goran Vladisavljevic
Format:	Default Article
Published:	2022
Subjects:	Step Microfluidic Emulsification Drug Delivery Drug-Eluting Medical Devices Biodegradable Polymer Poly(lactic-coglycolic acid) Controlled Drug Release
Online Access:	https://hdl.handle.net/2134/20146907.v1
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