Development of a process control strategy for the serum-free microcarrier expansion of human mesenchymal stem cells towards cost-effective and commercially viable manufacturing

Human Mesenchymal Stem Cells (hMSCs) are advancing through clinical development with the first allogeneic adult hMSC therapy receiving approval in Europe. To enable successful large-scale manufacture of hMSC therapies, increased product consistency and yield, and a reduced batch-to-batch variation m...

Full description

Bibliographic Details

Main Authors:	Thomas R.J. Heathman, Alvin W. Nienow, Qasim A. Rafiq, Karen Coopman, Bo Kara, Christopher J. Hewitt
Format:	Default Article
Published:	2018
Subjects:	Chemical engineering not elsewhere classified Process control Serum-free Human mesenchymal stem cell Microcarrier expansion Harvest Dissolved oxygen Chemical Engineering not elsewhere classified
Online Access:	https://hdl.handle.net/2134/37132
Tags:	Add Tag No Tags, Be the first to tag this record!