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Photo-crosslinkable microcapsules formed by polyelectrolyte copolymer and modified collagen for rat hepatocyte encapsulation
New anionic polyelectrolyte tetra-copolymers with photo-crosslinkable 4-(4-methoxycinnamoyl)phenyl methacrylate monomer in addition to a HEMA-MMA-MAA ter-copolymer system were synthesized. The tetra-copolymers were used to form photo-crosslinkable microcapsules with modified collagen by complex coac...
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| Main Authors: | , , , , , , , |
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| Format: | Default Article |
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2004
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| Online Access: | https://hdl.handle.net/2134/24975 |
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| _version_ | 1818171767518134272 |
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| author | Chai-Hoon Quek Jun Li Tao Sun Melinda Ling Hou Chan Hai-Quan Mao Leong Ming Gan Kam W. Leong Hanry Yu |
| author_facet | Chai-Hoon Quek Jun Li Tao Sun Melinda Ling Hou Chan Hai-Quan Mao Leong Ming Gan Kam W. Leong Hanry Yu |
| author_sort | Chai-Hoon Quek (7128401) |
| collection | Figshare |
| description | New anionic polyelectrolyte tetra-copolymers with photo-crosslinkable 4-(4-methoxycinnamoyl)phenyl methacrylate monomer in addition to a HEMA-MMA-MAA ter-copolymer system were synthesized. The tetra-copolymers were used to form photo-crosslinkable microcapsules with modified collagen by complex coacervation for rat hepatocytes encapsulation. The hepatocytes were encapsulated within a two-layered membrane comprising of modified collagen as the inner core and an outer photo-crosslinkable copolymer shell. Upon photo-crosslinking of the microcapsules with UV–Vis light irradiation, the mechanical strength and chemical stability of the microcapsules, and the cellular functions of the encapsulated hepatocytes were enhanced. Particularly, the mechanical stability of the microcapsules was dramatically strengthened. The new photo-crosslinkable tetra-copolymer formulation described in this article has opened a way to the development of hepatocyte microencapsulation technology for bioartifical liver assist device. |
| format | Default Article |
| id | rr-article-9240743 |
| institution | Loughborough University |
| publishDate | 2004 |
| record_format | Figshare |
| spelling | rr-article-92407432004-01-01T00:00:00Z Photo-crosslinkable microcapsules formed by polyelectrolyte copolymer and modified collagen for rat hepatocyte encapsulation Chai-Hoon Quek (7128401) Jun Li (6494) Tao Sun (1255119) Melinda Ling Hou Chan (7128398) Hai-Quan Mao (319217) Leong Ming Gan (2671582) Kam W. Leong (245979) Hanry Yu (172694) Chemical engineering not elsewhere classified Photo-crosslinking Microcapsule Cell-encapsulation Polyelectrolyte Collagen Hepatocyte Chemical Engineering not elsewhere classified New anionic polyelectrolyte tetra-copolymers with photo-crosslinkable 4-(4-methoxycinnamoyl)phenyl methacrylate monomer in addition to a HEMA-MMA-MAA ter-copolymer system were synthesized. The tetra-copolymers were used to form photo-crosslinkable microcapsules with modified collagen by complex coacervation for rat hepatocytes encapsulation. The hepatocytes were encapsulated within a two-layered membrane comprising of modified collagen as the inner core and an outer photo-crosslinkable copolymer shell. Upon photo-crosslinking of the microcapsules with UV–Vis light irradiation, the mechanical strength and chemical stability of the microcapsules, and the cellular functions of the encapsulated hepatocytes were enhanced. Particularly, the mechanical stability of the microcapsules was dramatically strengthened. The new photo-crosslinkable tetra-copolymer formulation described in this article has opened a way to the development of hepatocyte microencapsulation technology for bioartifical liver assist device. 2004-01-01T00:00:00Z Text Journal contribution 2134/24975 https://figshare.com/articles/journal_contribution/Photo-crosslinkable_microcapsules_formed_by_polyelectrolyte_copolymer_and_modified_collagen_for_rat_hepatocyte_encapsulation/9240743 CC BY-NC-ND 4.0 |
| spellingShingle | Chemical engineering not elsewhere classified Photo-crosslinking Microcapsule Cell-encapsulation Polyelectrolyte Collagen Hepatocyte Chemical Engineering not elsewhere classified Chai-Hoon Quek Jun Li Tao Sun Melinda Ling Hou Chan Hai-Quan Mao Leong Ming Gan Kam W. Leong Hanry Yu Photo-crosslinkable microcapsules formed by polyelectrolyte copolymer and modified collagen for rat hepatocyte encapsulation |
| title | Photo-crosslinkable microcapsules formed by polyelectrolyte copolymer and modified collagen for rat hepatocyte encapsulation |
| title_full | Photo-crosslinkable microcapsules formed by polyelectrolyte copolymer and modified collagen for rat hepatocyte encapsulation |
| title_fullStr | Photo-crosslinkable microcapsules formed by polyelectrolyte copolymer and modified collagen for rat hepatocyte encapsulation |
| title_full_unstemmed | Photo-crosslinkable microcapsules formed by polyelectrolyte copolymer and modified collagen for rat hepatocyte encapsulation |
| title_short | Photo-crosslinkable microcapsules formed by polyelectrolyte copolymer and modified collagen for rat hepatocyte encapsulation |
| title_sort | photo-crosslinkable microcapsules formed by polyelectrolyte copolymer and modified collagen for rat hepatocyte encapsulation |
| topic | Chemical engineering not elsewhere classified Photo-crosslinking Microcapsule Cell-encapsulation Polyelectrolyte Collagen Hepatocyte Chemical Engineering not elsewhere classified |
| url | https://hdl.handle.net/2134/24975 |