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The use of bioreactors as in vitro models in pharmaceutical research
Bringing a new drug to market is costly in terms of capital and time investments, and any development issues encountered during late-stage clinical trials can often be the result of in vitro-in vivo extrapolations (IVIVE) not accurately reflecting clinical outcome. In the discipline of drug metaboli...
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| Main Authors: | , , , , , |
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| Format: | Default Article |
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2013
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| Online Access: | https://hdl.handle.net/2134/14245 |
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| _version_ | 1818173608302739456 |
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| author | Maaria Ginai Robert Elsby Christopher Hewitt Dominic Surry Katherine Fenner Karen Coopman |
| author_facet | Maaria Ginai Robert Elsby Christopher Hewitt Dominic Surry Katherine Fenner Karen Coopman |
| author_sort | Maaria Ginai (1384650) |
| collection | Figshare |
| description | Bringing a new drug to market is costly in terms of capital and time investments, and any development issues encountered during late-stage clinical trials can often be the result of in vitro-in vivo extrapolations (IVIVE) not accurately reflecting clinical outcome. In the discipline of drug metabolism and pharmacokinetics (DMPK), current in vitro cellular methods do not provide the 3D structure and function of organs found in vivo; therefore, new dynamic methods need to be established to aid improvement of IVIVE. In this review, we highlight the importance of model progression into dynamic systems for use within drug development, focusing on devices developed currently in the areas of the liver and blood-brain barrier (BBB), and the potential to develop models for other organ systems, such as the kidney. We discuss the development of dynamic 3D bioreactor-based systems as in vitro models for use in DMPK studies. |
| format | Default Article |
| id | rr-article-9241934 |
| institution | Loughborough University |
| publishDate | 2013 |
| record_format | Figshare |
| spelling | rr-article-92419342013-01-01T00:00:00Z The use of bioreactors as in vitro models in pharmaceutical research Maaria Ginai (1384650) Robert Elsby (7129091) Christopher Hewitt (1253757) Dominic Surry (2398948) Katherine Fenner (7129094) Karen Coopman (1171644) Chemical engineering not elsewhere classified untagged Chemical Engineering not elsewhere classified Bringing a new drug to market is costly in terms of capital and time investments, and any development issues encountered during late-stage clinical trials can often be the result of in vitro-in vivo extrapolations (IVIVE) not accurately reflecting clinical outcome. In the discipline of drug metabolism and pharmacokinetics (DMPK), current in vitro cellular methods do not provide the 3D structure and function of organs found in vivo; therefore, new dynamic methods need to be established to aid improvement of IVIVE. In this review, we highlight the importance of model progression into dynamic systems for use within drug development, focusing on devices developed currently in the areas of the liver and blood-brain barrier (BBB), and the potential to develop models for other organ systems, such as the kidney. We discuss the development of dynamic 3D bioreactor-based systems as in vitro models for use in DMPK studies. 2013-01-01T00:00:00Z Text Journal contribution 2134/14245 https://figshare.com/articles/journal_contribution/The_use_of_bioreactors_as_in_vitro_models_in_pharmaceutical_research/9241934 CC BY-NC-ND 4.0 |
| spellingShingle | Chemical engineering not elsewhere classified untagged Chemical Engineering not elsewhere classified Maaria Ginai Robert Elsby Christopher Hewitt Dominic Surry Katherine Fenner Karen Coopman The use of bioreactors as in vitro models in pharmaceutical research |
| title | The use of bioreactors as in vitro models in pharmaceutical research |
| title_full | The use of bioreactors as in vitro models in pharmaceutical research |
| title_fullStr | The use of bioreactors as in vitro models in pharmaceutical research |
| title_full_unstemmed | The use of bioreactors as in vitro models in pharmaceutical research |
| title_short | The use of bioreactors as in vitro models in pharmaceutical research |
| title_sort | use of bioreactors as in vitro models in pharmaceutical research |
| topic | Chemical engineering not elsewhere classified untagged Chemical Engineering not elsewhere classified |
| url | https://hdl.handle.net/2134/14245 |