Scalability and process transfer of mesenchymal stromal cell production from monolayer to microcarrier culture using human platelet lysate

Background: The selection of medium and associated reagents for human mesenchymal stromal cell (hMSC) culture forms an integral part of manufacturing process development and must be suitable for multiple process scales and expansion technologies. Methods: In this work, we have expanded BM-hMSCs in f...

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Bibliographic Details

Main Authors:	Thomas Heathman, Alexandra Stolzing, Claire Fabian, Qasim A. Rafiq, Karen Coopman, Alvin W. Nienow, Bo Kara, Christopher J. Hewitt
Format:	Default Article
Published:	2016
Subjects:	Chemical engineering not elsewhere classified Human platelet lysate Mesenchymal stromal cell Microcarrier expansion Manufacture Bioprocess Cell-based therapy Process transfer Comparability Process development Harvest Chemical Engineering not elsewhere classified
Online Access:	https://hdl.handle.net/2134/20224
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