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Model-based design of a plant-wide control strategy for a continuous pharmaceutical plant
The design of an effective plant-wide control strategy is a key challenge for the development of future continuous pharmaceutical processes. This article presents a case study for the design of a plant-wide control structure for a system inspired by an end-to-end continuous pharmaceutical pilot plan...
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| Main Authors: | , , , |
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| Format: | Default Article |
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2013
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| Online Access: | https://hdl.handle.net/2134/15277 |
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| _version_ | 1818173419544379392 |
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| author | Richard Lakerveld Brahim Benyahia Richard D. Braatz Paul I. Barton |
| author_facet | Richard Lakerveld Brahim Benyahia Richard D. Braatz Paul I. Barton |
| author_sort | Richard Lakerveld (1784755) |
| collection | Figshare |
| description | The design of an effective plant-wide control strategy is a key challenge for the development of future continuous pharmaceutical processes. This article presents a case study for the design of a plant-wide control structure for a system inspired by an end-to-end continuous pharmaceutical pilot plant. A hierarchical decomposition strategy is used to classify control objectives. A plant-wide dynamic model of the process is used to generate parametric sensitivities, which provide a basis for the synthesis of control loops. Simulations for selected disturbances illustrate that the critical quality attributes (CQAs) of the final product can be kept close to specification in the presence of significant and persistent disturbances. Furthermore, it is illustrated how selected CQAs of the final product can be brought simultaneously to a new setpoint while maintaining the remaining CQAs at a constant value during this transition. The latter result shows flexibility to control CQAs independently of each other. |
| format | Default Article |
| id | rr-article-9243833 |
| institution | Loughborough University |
| publishDate | 2013 |
| record_format | Figshare |
| spelling | rr-article-92438332013-01-01T00:00:00Z Model-based design of a plant-wide control strategy for a continuous pharmaceutical plant Richard Lakerveld (1784755) Brahim Benyahia (1258056) Richard D. Braatz (784631) Paul I. Barton (1717336) Chemical engineering not elsewhere classified Process control Design (process simulation) Plant-wide control Continuous pharmaceutical manufacturing Sensitivity analysis Chemical Engineering not elsewhere classified The design of an effective plant-wide control strategy is a key challenge for the development of future continuous pharmaceutical processes. This article presents a case study for the design of a plant-wide control structure for a system inspired by an end-to-end continuous pharmaceutical pilot plant. A hierarchical decomposition strategy is used to classify control objectives. A plant-wide dynamic model of the process is used to generate parametric sensitivities, which provide a basis for the synthesis of control loops. Simulations for selected disturbances illustrate that the critical quality attributes (CQAs) of the final product can be kept close to specification in the presence of significant and persistent disturbances. Furthermore, it is illustrated how selected CQAs of the final product can be brought simultaneously to a new setpoint while maintaining the remaining CQAs at a constant value during this transition. The latter result shows flexibility to control CQAs independently of each other. 2013-01-01T00:00:00Z Text Journal contribution 2134/15277 https://figshare.com/articles/journal_contribution/Model-based_design_of_a_plant-wide_control_strategy_for_a_continuous_pharmaceutical_plant/9243833 CC BY-NC-ND 4.0 |
| spellingShingle | Chemical engineering not elsewhere classified Process control Design (process simulation) Plant-wide control Continuous pharmaceutical manufacturing Sensitivity analysis Chemical Engineering not elsewhere classified Richard Lakerveld Brahim Benyahia Richard D. Braatz Paul I. Barton Model-based design of a plant-wide control strategy for a continuous pharmaceutical plant |
| title | Model-based design of a plant-wide control strategy for a continuous pharmaceutical plant |
| title_full | Model-based design of a plant-wide control strategy for a continuous pharmaceutical plant |
| title_fullStr | Model-based design of a plant-wide control strategy for a continuous pharmaceutical plant |
| title_full_unstemmed | Model-based design of a plant-wide control strategy for a continuous pharmaceutical plant |
| title_short | Model-based design of a plant-wide control strategy for a continuous pharmaceutical plant |
| title_sort | model-based design of a plant-wide control strategy for a continuous pharmaceutical plant |
| topic | Chemical engineering not elsewhere classified Process control Design (process simulation) Plant-wide control Continuous pharmaceutical manufacturing Sensitivity analysis Chemical Engineering not elsewhere classified |
| url | https://hdl.handle.net/2134/15277 |