Scale-down studies for assessing the impact of different stress parameters on growth and product quality during animal cell culture

Two series of reproducible fed-batch bench scale cultures have been undertaken, one series simulating the impact of spatial variations in pH and nutrients as found at commercial scale on performance, the other, the impact of fluid dynamic stresses associated with agitation. The first was unsuccessfu...

Full description

Saved in:
Bibliographic Details
Main Authors: Alvin W. Nienow, William H. Scott, Christopher Hewitt, Colin R. Thomas, Gareth Lewis, Ashraf Amanullah, Robert Kiss, Steven J. Meier
Format: Default Article
Published: 2013
Subjects:
Chemical engineering not elsewhere classified
CHO cells
Mechanical stress
Kolmogorov scale of turbulence
Environmental stress
Product quality
Glycosolation
Process performance
Chemical Engineering not elsewhere classified
Online Access:https://hdl.handle.net/2134/14846
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://hdl.handle.net/2134/14846

Similar Items