Integrated system for temperature-controlled fast protein liquid chromatography comprising improved copolymer modified beaded agarose adsorbents and a travelling cooling zone reactor arrangement

An integrated approach to temperature-controlled chromatography, involving copolymer modified agarose adsorbents and a novel travelling cooling zone reactor (TCZR) arrangement, is described. Sepharose CL6B was transformed into a thermoresponsive cation exchange adsorbent (thermoCEX) in four syntheti...

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Bibliographic Details
Main Authors: Tobias K.H. Muller, Ping Cao, Stephanie Ewert, Jonas Wohlgemuth, Matthias Franzreb, Haiyang Liu, Thomas C. Willett, Eirini Theodosiou, Owen R.T. Thomas
Format: Default Article
Published: 2013
Subjects:
Chemical engineering not elsewhere classified
Bioseparation
Ion exchange adsorption
Lactoferrin
Lower critical solution temperature (LCST)
N-isopropylacrylamide
Smart polymers
Chemical Engineering not elsewhere classified
Online Access:https://hdl.handle.net/2134/12018
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https://hdl.handle.net/2134/12018

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