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Warm hands, cold heart: progressive whole-body cooling increases warm thermosensitivity of human hands and feet in a dose-dependent fashion
While inhibitory/facilitatory central modulation of vision and pain has been investigated, contextual modulation of skin temperature integration has been unexplored. Hence, we tested whether progressive decreases in whole-body mean skin temperature (Tsk) (a large conditioning stimulus) alter the mag...
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| Format: | Default Article |
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2017
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| Online Access: | https://hdl.handle.net/2134/23271 |
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| _version_ | 1818171616155140096 |
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| author | Davide Filingeri Nathan B. Morris Oliver E. Jay |
| author_facet | Davide Filingeri Nathan B. Morris Oliver E. Jay |
| author_sort | Davide Filingeri (3135528) |
| collection | Figshare |
| description | While inhibitory/facilitatory central modulation of vision and pain has been investigated, contextual modulation of skin temperature integration has been unexplored. Hence, we tested whether progressive decreases in whole-body mean skin temperature (Tsk) (a large conditioning stimulus) alter the magnitude estimation of local warming and cooling stimuli applied to hairy and glabrous skin. On 4 separate occasions, 8 males (27 ± 5y) underwent a 30-min whole-body cooling protocol (water-perfused-suit; temperature: 5 C), during which a quantitative thermosensory test, consisting of reporting perceived magnitude of warming and cooling stimuli (±8°C from 30°C baseline) applied to the hand (palm/dorsum) and foot (sole/dorsum), was performed before cooling and every 10 min thereafter. The cooling protocol resulted in large progressive reductions in whole-body Tsk (10 min: -3.36 C (95% CI: -2.62, -4.10); 20 min: −5.21°C (−4.47, -5.95); 30 min: −6.32°C ( −5.58, -7.05); P < 0.001), with minimal changes (∼0.08 C) in rectal temperature. While thermosensitivity to local skin cooling remained unchanged (P = 0.831), sensitivity to skin warming increased significantly at each level of whole-body Tsk for all skin regions (10 min: +4.9% (−1.1, +11.0); 20 min: +6.1% (+0.1, 12.2); 30 min: +7.9% (+1.9, +13.9); P = 0.009). Linear regression indicated a 1.2%.°C−1 increase in warm thermosensitivity with whole-body skin cooling. Overall, large decreases in whole-body Tsk significantly facilitated warm, but not cold, sensory processing of local thermal stimuli, in a dose-dependent fashion. In highlighting a novel feature of human temperature integration, these findings point to the existence of an endogenous thermosensory system that could modulate local skin thermal sensitivity in relation to whole-body thermal states. |
| format | Default Article |
| id | rr-article-9347960 |
| institution | Loughborough University |
| publishDate | 2017 |
| record_format | Figshare |
| spelling | rr-article-93479602017-01-01T00:00:00Z Warm hands, cold heart: progressive whole-body cooling increases warm thermosensitivity of human hands and feet in a dose-dependent fashion Davide Filingeri (3135528) Nathan B. Morris (7152902) Oliver E. Jay (7149581) Animal physiology - biophysics Animal physiology - cell Animal physiology - systems Design not elsewhere classified Body temperature regulation Nervous system Thermoreceptors Perception Skin Physiology Design Practice and Management not elsewhere classified While inhibitory/facilitatory central modulation of vision and pain has been investigated, contextual modulation of skin temperature integration has been unexplored. Hence, we tested whether progressive decreases in whole-body mean skin temperature (Tsk) (a large conditioning stimulus) alter the magnitude estimation of local warming and cooling stimuli applied to hairy and glabrous skin. On 4 separate occasions, 8 males (27 ± 5y) underwent a 30-min whole-body cooling protocol (water-perfused-suit; temperature: 5 C), during which a quantitative thermosensory test, consisting of reporting perceived magnitude of warming and cooling stimuli (±8°C from 30°C baseline) applied to the hand (palm/dorsum) and foot (sole/dorsum), was performed before cooling and every 10 min thereafter. The cooling protocol resulted in large progressive reductions in whole-body Tsk (10 min: -3.36 C (95% CI: -2.62, -4.10); 20 min: −5.21°C (−4.47, -5.95); 30 min: −6.32°C ( −5.58, -7.05); P < 0.001), with minimal changes (∼0.08 C) in rectal temperature. While thermosensitivity to local skin cooling remained unchanged (P = 0.831), sensitivity to skin warming increased significantly at each level of whole-body Tsk for all skin regions (10 min: +4.9% (−1.1, +11.0); 20 min: +6.1% (+0.1, 12.2); 30 min: +7.9% (+1.9, +13.9); P = 0.009). Linear regression indicated a 1.2%.°C−1 increase in warm thermosensitivity with whole-body skin cooling. Overall, large decreases in whole-body Tsk significantly facilitated warm, but not cold, sensory processing of local thermal stimuli, in a dose-dependent fashion. In highlighting a novel feature of human temperature integration, these findings point to the existence of an endogenous thermosensory system that could modulate local skin thermal sensitivity in relation to whole-body thermal states. 2017-01-01T00:00:00Z Text Journal contribution 2134/23271 https://figshare.com/articles/journal_contribution/Warm_hands_cold_heart_progressive_whole-body_cooling_increases_warm_thermosensitivity_of_human_hands_and_feet_in_a_dose-dependent_fashion/9347960 CC BY-NC-ND 4.0 |
| spellingShingle | Animal physiology - biophysics Animal physiology - cell Animal physiology - systems Design not elsewhere classified Body temperature regulation Nervous system Thermoreceptors Perception Skin Physiology Design Practice and Management not elsewhere classified Davide Filingeri Nathan B. Morris Oliver E. Jay Warm hands, cold heart: progressive whole-body cooling increases warm thermosensitivity of human hands and feet in a dose-dependent fashion |
| title | Warm hands, cold heart: progressive whole-body cooling increases warm thermosensitivity of human hands and feet in a dose-dependent fashion |
| title_full | Warm hands, cold heart: progressive whole-body cooling increases warm thermosensitivity of human hands and feet in a dose-dependent fashion |
| title_fullStr | Warm hands, cold heart: progressive whole-body cooling increases warm thermosensitivity of human hands and feet in a dose-dependent fashion |
| title_full_unstemmed | Warm hands, cold heart: progressive whole-body cooling increases warm thermosensitivity of human hands and feet in a dose-dependent fashion |
| title_short | Warm hands, cold heart: progressive whole-body cooling increases warm thermosensitivity of human hands and feet in a dose-dependent fashion |
| title_sort | warm hands, cold heart: progressive whole-body cooling increases warm thermosensitivity of human hands and feet in a dose-dependent fashion |
| topic | Animal physiology - biophysics Animal physiology - cell Animal physiology - systems Design not elsewhere classified Body temperature regulation Nervous system Thermoreceptors Perception Skin Physiology Design Practice and Management not elsewhere classified |
| url | https://hdl.handle.net/2134/23271 |