Efficient oxygen transfer by surface aeration in shaken cylindrical containers for mammalian cell cultivation at volumetric scales up to 1000 L

Cylindrical containers agitated by orbital shaking are being developed as simple and cost-effective bioreactor systems for the cultivation of mammalian cells. Here the oxygen transfer capacities of containers with nominal volumes from 50 mL to 2000 L were determined, and the operating parameters inf...

Full description

Saved in:
Bibliographic Details
Main Authors: Xiaowei Zhang, Cedric-Alain Burki, Matthieu Stettler, Dario De Sanctis, Marco Perrone, Marco Discacciati, Nicola Parolini, Maria De Jesus, David Hacker, Alfio Quarteroni, Florian M. Wurm
Format: Default Article
Published: 2009
Subjects:
Other mathematical sciences not elsewhere classified
Bioreactor
Agitation
Animal cell culture
Oxygen transfer
Scale-up
Aeration
Mathematical Sciences not elsewhere classified
Online Access:https://hdl.handle.net/2134/18731
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items