Rapid analysis of N-methylpyrrolidine in cefepime with thermal desorption ion mobility spectrometry

N-methyl-pyrrolidine (NMP) a potential impurity in the cephalosporin antibiotic cefepime is analysed using a rapid thermal desorption – ion mobility spectrometry (TD-IMS) method. The thermal desorption approach is shown to be capable of rapidly extracting NMP from the cefepime at 80 °C without causi...

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Bibliographic Details
Main Authors: Jim Reynolds, Laura Giddings, Ime C. Usen, Haodong Cheng, Junmin Shan, Matthew Turner, Colin Creaser
Format: Default Article
Published: 2016
Subjects:
Other chemical sciences not elsewhere classified
Ion mobility
Pharmaceutical impurities
Direct analysis
Thermal desorption
HPLC
Chemical Sciences not elsewhere classified
Online Access:https://hdl.handle.net/2134/24347
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https://hdl.handle.net/2134/24347

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