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Synthetic and antimicrobial studies of nitroimidazole analogues
New 2-, 4- and 5-nitroimidazole analogues were synthesised using the following methods: (i) SRN1 free radical reaction between nitroimidazole anion and halonitro substrates; (ii) oxidative addition of the anion of 2-nitropropane to nitroimidazole anions. N-1-alkyl derivatives of imidazole, benzimida...
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| Format: | Default Thesis |
| Published: |
1988
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| Online Access: | https://hdl.handle.net/2134/32020 |
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| Summary: | New 2-, 4- and 5-nitroimidazole analogues were synthesised using the following methods: (i) SRN1 free radical reaction between nitroimidazole anion and halonitro substrates; (ii) oxidative addition of the anion of 2-nitropropane to nitroimidazole anions. N-1-alkyl derivatives of imidazole, benzimidazole, 5-nitrobenzimidazole, 5- and 6-nitroindazole were similarly prepared. These compounds showed antimicrobial activity; anaerobes were more sensitive than aerobes. [Continues.] |
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