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Synthetic approach to the novel cholecystokinin (CCK)-B receptor antagonist tetronothiodin
The thesis consists first of an introduction discussing CCK-receptor antagonists and the role tetronothiodin plays. There is a section on the isolation and characterisation of the tetronothiodin structure. This leads to a retrosynthesis of the compound and the synthetic plan towards forming the oxas...
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| Format: | Default Thesis |
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2002
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| Online Access: | https://hdl.handle.net/2134/34061 |
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| _version_ | 1818169474296053760 |
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| author | Kevin J. Batchelor |
| author_facet | Kevin J. Batchelor |
| author_sort | Kevin J. Batchelor (7167422) |
| collection | Figshare |
| description | The thesis consists first of an introduction discussing CCK-receptor antagonists and the role tetronothiodin plays. There is a section on the isolation and characterisation of the tetronothiodin structure. This leads to a retrosynthesis of the compound and the synthetic plan towards forming the oxaspirobicyclic moiety. The introduction includes the initial ideas for the construction of this subunit, with analogous subunits in the literature being discussed. A brief review of the likely chemistry is discussed. The second chapter is the results and discussion section, beginning with the formation of the Diels–Alder precursors and the chemistry used to form a suitably functionalised cyclohexene rings with the aim of forming the cyclohexenone. [Continues.] |
| format | Default Thesis |
| id | rr-article-9400211 |
| institution | Loughborough University |
| publishDate | 2002 |
| record_format | Figshare |
| spelling | rr-article-94002112002-01-01T00:00:00Z Synthetic approach to the novel cholecystokinin (CCK)-B receptor antagonist tetronothiodin Kevin J. Batchelor (7167422) Other chemical sciences not elsewhere classified untagged Chemical Sciences not elsewhere classified The thesis consists first of an introduction discussing CCK-receptor antagonists and the role tetronothiodin plays. There is a section on the isolation and characterisation of the tetronothiodin structure. This leads to a retrosynthesis of the compound and the synthetic plan towards forming the oxaspirobicyclic moiety. The introduction includes the initial ideas for the construction of this subunit, with analogous subunits in the literature being discussed. A brief review of the likely chemistry is discussed. The second chapter is the results and discussion section, beginning with the formation of the Diels–Alder precursors and the chemistry used to form a suitably functionalised cyclohexene rings with the aim of forming the cyclohexenone. [Continues.] 2002-01-01T00:00:00Z Text Thesis 2134/34061 https://figshare.com/articles/thesis/Synthetic_approach_to_the_novel_cholecystokinin_CCK_-B_receptor_antagonist_tetronothiodin/9400211 CC BY-NC-ND 4.0 |
| spellingShingle | Other chemical sciences not elsewhere classified untagged Chemical Sciences not elsewhere classified Kevin J. Batchelor Synthetic approach to the novel cholecystokinin (CCK)-B receptor antagonist tetronothiodin |
| title | Synthetic approach to the novel cholecystokinin (CCK)-B receptor antagonist tetronothiodin |
| title_full | Synthetic approach to the novel cholecystokinin (CCK)-B receptor antagonist tetronothiodin |
| title_fullStr | Synthetic approach to the novel cholecystokinin (CCK)-B receptor antagonist tetronothiodin |
| title_full_unstemmed | Synthetic approach to the novel cholecystokinin (CCK)-B receptor antagonist tetronothiodin |
| title_short | Synthetic approach to the novel cholecystokinin (CCK)-B receptor antagonist tetronothiodin |
| title_sort | synthetic approach to the novel cholecystokinin (cck)-b receptor antagonist tetronothiodin |
| topic | Other chemical sciences not elsewhere classified untagged Chemical Sciences not elsewhere classified |
| url | https://hdl.handle.net/2134/34061 |