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Estrogen status and the renin angiotensin aldosterone system
The renin-angiotensin-aldosterone system (RAAS) is integrally involved in multiple cardiovascular physiological processes including arterial blood pressure (BP) regulation. Over activity of the RAAS has been implicated in the pathogenesis of a number of cardiovascular disease entities, including hyp...
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| Format: | Default Article |
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2014
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| Online Access: | https://hdl.handle.net/2134/20625 |
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| _version_ | 1818172264060813312 |
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| author | Emma ODonnell John S. Floras Paula J. Harvey |
| author_facet | Emma ODonnell John S. Floras Paula J. Harvey |
| author_sort | Emma ODonnell (1384770) |
| collection | Figshare |
| description | The renin-angiotensin-aldosterone system (RAAS) is integrally involved in multiple cardiovascular physiological processes including arterial blood pressure (BP) regulation. Over activity of the RAAS has been implicated in the pathogenesis of a number of cardiovascular disease entities, including hypertension. Several lines of evidence suggest estrogen favorably modulates the RAAS. Conversely, estrogen deficiency due to menopause may contribute to over activity of the RAAS. Of importance, estrogen deficiency in women is not exclusive to the postmenopausal period. Functional hypothalamic amenorrhea is a reversible cause of premenopausal hypoestrogenemia. In contrast to postmenopausal women (PMW), premenopausal women with exercise-associated functional hypothalamic amenorrhea demonstrate decreased, not increased, resting BP compared with their estrogen-replete eumenorrheic counterpart. In this review we briefly examine the effects of estrogen status on the RAAS and present the hypothesis that the RAAS is altered in physically active women with functional hypothalamic amenorrhea. |
| format | Default Article |
| id | rr-article-9611546 |
| institution | Loughborough University |
| publishDate | 2014 |
| record_format | Figshare |
| spelling | rr-article-96115462014-01-01T00:00:00Z Estrogen status and the renin angiotensin aldosterone system Emma ODonnell (1384770) John S. Floras (7239164) Paula J. Harvey (7238525) Other health sciences not elsewhere classified Amenorrhea Estrogens Energy deficiency Exercise Ovarian disruption Medical and Health Sciences not elsewhere classified The renin-angiotensin-aldosterone system (RAAS) is integrally involved in multiple cardiovascular physiological processes including arterial blood pressure (BP) regulation. Over activity of the RAAS has been implicated in the pathogenesis of a number of cardiovascular disease entities, including hypertension. Several lines of evidence suggest estrogen favorably modulates the RAAS. Conversely, estrogen deficiency due to menopause may contribute to over activity of the RAAS. Of importance, estrogen deficiency in women is not exclusive to the postmenopausal period. Functional hypothalamic amenorrhea is a reversible cause of premenopausal hypoestrogenemia. In contrast to postmenopausal women (PMW), premenopausal women with exercise-associated functional hypothalamic amenorrhea demonstrate decreased, not increased, resting BP compared with their estrogen-replete eumenorrheic counterpart. In this review we briefly examine the effects of estrogen status on the RAAS and present the hypothesis that the RAAS is altered in physically active women with functional hypothalamic amenorrhea. 2014-01-01T00:00:00Z Text Journal contribution 2134/20625 https://figshare.com/articles/journal_contribution/Estrogen_status_and_the_renin_angiotensin_aldosterone_system/9611546 CC BY-NC-ND 4.0 |
| spellingShingle | Other health sciences not elsewhere classified Amenorrhea Estrogens Energy deficiency Exercise Ovarian disruption Medical and Health Sciences not elsewhere classified Emma ODonnell John S. Floras Paula J. Harvey Estrogen status and the renin angiotensin aldosterone system |
| title | Estrogen status and the renin angiotensin aldosterone system |
| title_full | Estrogen status and the renin angiotensin aldosterone system |
| title_fullStr | Estrogen status and the renin angiotensin aldosterone system |
| title_full_unstemmed | Estrogen status and the renin angiotensin aldosterone system |
| title_short | Estrogen status and the renin angiotensin aldosterone system |
| title_sort | estrogen status and the renin angiotensin aldosterone system |
| topic | Other health sciences not elsewhere classified Amenorrhea Estrogens Energy deficiency Exercise Ovarian disruption Medical and Health Sciences not elsewhere classified |
| url | https://hdl.handle.net/2134/20625 |