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The effect of prior walking on coronary heart disease risk markers in South Asian and European men
Purpose: Heart disease risk is elevated in South Asians possibly due to impaired postprandial metabolism. Running has been shown to induce greater reductions in postprandial lipaemia in South Asian than European men but the effect of walking in South Asians is unknown. Methods: Fifteen South Asian a...
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| Format: | Default Article |
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2015
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| Online Access: | https://hdl.handle.net/2134/19119 |
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| _version_ | 1818172594827821056 |
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| author | Saravana P. Arjunan Kevin Deighton Nicolette Bishop James King Alvaro Reischak-Oliveira Alice Rogan Matthew J. Sedgewick Alice Thackray David Webb David Stensel |
| author_facet | Saravana P. Arjunan Kevin Deighton Nicolette Bishop James King Alvaro Reischak-Oliveira Alice Rogan Matthew J. Sedgewick Alice Thackray David Webb David Stensel |
| author_sort | Saravana P. Arjunan (7237742) |
| collection | Figshare |
| description | Purpose: Heart disease risk is elevated in South Asians possibly due to impaired postprandial metabolism. Running has been shown to induce greater reductions in postprandial lipaemia in South Asian than European men but the effect of walking in South Asians is unknown. Methods: Fifteen South Asian and 14 White European men aged 19-30 years completed two, 2-d trials in a randomised crossover design. On day 1, participants rested (control) or walked for 60 min at approximately 50% maximum oxygen uptake (exercise). On day 2, participants rested and consumed two high fat meals over a 9h period during which 14 venous blood samples were collected. Results: South Asians exhibited higher postprandial triacylglycerol (geometric mean (95% confidence interval) 2.29(1.82 to 2.89) vs. 1.54(1.21 to 1.96) mmol·L-1·hr-1), glucose (5.49(5.21 to 5.79) vs. 5.05(4.78 to 5.33) mmol·L-1·hr-1), insulin (32.9(25.7 to 42.1) vs. 18.3(14.2 to 23.7) μU·mL-1·hr-1) and interleukin-6 (2.44(1.61 to 3.67) vs. 1.04(0.68 to 1.59) pg·mL-1·hr-1) than Europeans (all ES ≥ 0.72, P≤0.03). Between-group differences in triacylglycerol, glucose and insulin were not significant after controlling for age and percentage body fat. Walking reduced postprandial triacylglycerol (1.79(1.52 to 2.12) vs. 1.97(1.67 to 2.33) mmol·L-1·hr-1) and insulin (21.0(17.0 to 26.0) vs. 28.7(23.2 to 35.4) μU·mL-1·hr-1) (all ES ≥ 0.23. P≤0.01), but group differences were not significant. Conclusions: Healthy South Asians exhibited impaired postprandial metabolism compared with White Europeans, but these differences were diminished after controlling for potential confounders. The small-moderate reduction in postprandial triacylglycerol and insulin after brisk walking was not different between the ethnicities. |
| format | Default Article |
| id | rr-article-9617312 |
| institution | Loughborough University |
| publishDate | 2015 |
| record_format | Figshare |
| spelling | rr-article-96173122015-01-01T00:00:00Z The effect of prior walking on coronary heart disease risk markers in South Asian and European men Saravana P. Arjunan (7237742) Kevin Deighton (4775292) Nicolette Bishop (1255977) James King (1252200) Alvaro Reischak-Oliveira (7241735) Alice Rogan (7241738) Matthew J. Sedgewick (7241741) Alice Thackray (1251621) David Webb (294780) David Stensel (1257075) Other health sciences not elsewhere classified Cardiovascular disease Exercise Inflammation Postprandial lipaemia Physical activity Medical and Health Sciences not elsewhere classified Purpose: Heart disease risk is elevated in South Asians possibly due to impaired postprandial metabolism. Running has been shown to induce greater reductions in postprandial lipaemia in South Asian than European men but the effect of walking in South Asians is unknown. Methods: Fifteen South Asian and 14 White European men aged 19-30 years completed two, 2-d trials in a randomised crossover design. On day 1, participants rested (control) or walked for 60 min at approximately 50% maximum oxygen uptake (exercise). On day 2, participants rested and consumed two high fat meals over a 9h period during which 14 venous blood samples were collected. Results: South Asians exhibited higher postprandial triacylglycerol (geometric mean (95% confidence interval) 2.29(1.82 to 2.89) vs. 1.54(1.21 to 1.96) mmol·L-1·hr-1), glucose (5.49(5.21 to 5.79) vs. 5.05(4.78 to 5.33) mmol·L-1·hr-1), insulin (32.9(25.7 to 42.1) vs. 18.3(14.2 to 23.7) μU·mL-1·hr-1) and interleukin-6 (2.44(1.61 to 3.67) vs. 1.04(0.68 to 1.59) pg·mL-1·hr-1) than Europeans (all ES ≥ 0.72, P≤0.03). Between-group differences in triacylglycerol, glucose and insulin were not significant after controlling for age and percentage body fat. Walking reduced postprandial triacylglycerol (1.79(1.52 to 2.12) vs. 1.97(1.67 to 2.33) mmol·L-1·hr-1) and insulin (21.0(17.0 to 26.0) vs. 28.7(23.2 to 35.4) μU·mL-1·hr-1) (all ES ≥ 0.23. P≤0.01), but group differences were not significant. Conclusions: Healthy South Asians exhibited impaired postprandial metabolism compared with White Europeans, but these differences were diminished after controlling for potential confounders. The small-moderate reduction in postprandial triacylglycerol and insulin after brisk walking was not different between the ethnicities. 2015-01-01T00:00:00Z Text Journal contribution 2134/19119 https://figshare.com/articles/journal_contribution/The_effect_of_prior_walking_on_coronary_heart_disease_risk_markers_in_South_Asian_and_European_men/9617312 CC BY-NC-ND 4.0 |
| spellingShingle | Other health sciences not elsewhere classified Cardiovascular disease Exercise Inflammation Postprandial lipaemia Physical activity Medical and Health Sciences not elsewhere classified Saravana P. Arjunan Kevin Deighton Nicolette Bishop James King Alvaro Reischak-Oliveira Alice Rogan Matthew J. Sedgewick Alice Thackray David Webb David Stensel The effect of prior walking on coronary heart disease risk markers in South Asian and European men |
| title | The effect of prior walking on coronary heart disease risk markers in South Asian and European men |
| title_full | The effect of prior walking on coronary heart disease risk markers in South Asian and European men |
| title_fullStr | The effect of prior walking on coronary heart disease risk markers in South Asian and European men |
| title_full_unstemmed | The effect of prior walking on coronary heart disease risk markers in South Asian and European men |
| title_short | The effect of prior walking on coronary heart disease risk markers in South Asian and European men |
| title_sort | effect of prior walking on coronary heart disease risk markers in south asian and european men |
| topic | Other health sciences not elsewhere classified Cardiovascular disease Exercise Inflammation Postprandial lipaemia Physical activity Medical and Health Sciences not elsewhere classified |
| url | https://hdl.handle.net/2134/19119 |