GDF15 provides an endocrine signal of nutritional stress in mice and humans

GDF15 is an established biomarker of cellular stress. The fact that it signals via a specific hindbrain receptor, GFRAL, and that mice lacking GDF15 manifest diet-induced obesity suggest that GDF15 may play a physiological role in energy balance. We performed experiments in humans, mice, and cells t...

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Main Authors: Satish Patel, Anna Alvarez-Guaita, Audrey Melvin, Debra Rimmington, Alessia Dattilo, Emily L. Miedzybrodzka, Irene Cimino, Anne-Catherine Maurin, Geoffrey P. Roberts, Claire L. Meek, Samuel Virtue, Lauren M. Sparks, Stephanie A. Parsons, Leanne M. Redman, George A. Bray, Alice P. Liou, Rachel M. Woods, Sion A. Parry, Per B. Jeppesen, Anders J. Kolnes, Heather P. Harding, David Ron, Antonio Vidal-Puig, Frank Reimann, Fiona M. Gribble, Carl Hulston, I. Sadaf Farooqi, Pierre Fafournoux, Steven R. Smith, Jorgen Jensen, Danna Breen, Zhidan Wu, Bei B. Zhang, Anthony P. Coll, David B. Savage, Stephen O’Rahilly
Format: Default Article
Published: 2019
Subjects:
Other health sciences not elsewhere classified
GDF15
GFRAL
Integrated stress response
Overnutrion
Conditioned taste aversion
Medical and Health Sciences not elsewhere classified
Online Access:https://hdl.handle.net/2134/36744
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https://hdl.handle.net/2134/36744

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