Loading…
Editor’s choice-Biomarkers of acute cardiovascular and pulmonary diseases
Acute cardiothoracic and respiratory diseases frequently remain a challenge to diagnose and differentiate in the emergency setting. The main diseases that manifest with chest pain include ischaemic heart disease, myocarditis, acute pericarditis, aortic dissection/rupture and pulmonary embolism (PE)....
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Default Article |
| Published: |
2016
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/2134/33313 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1822542648464900096 |
|---|---|
| author | Toru Suzuki Alexander Lyon Rajeev Saggar Liam Heaney Kenichi Aizawa Antonio Cittadini Ciro Mauro Rodolfo Citro Giuseppe Limongelli Francesco Ferrara Olga Vriz Andrew Morley-Smith Paolo Calabro Eduardo Bossone |
| author_facet | Toru Suzuki Alexander Lyon Rajeev Saggar Liam Heaney Kenichi Aizawa Antonio Cittadini Ciro Mauro Rodolfo Citro Giuseppe Limongelli Francesco Ferrara Olga Vriz Andrew Morley-Smith Paolo Calabro Eduardo Bossone |
| author_sort | Toru Suzuki (512729) |
| collection | Figshare |
| description | Acute cardiothoracic and respiratory diseases frequently remain a challenge to diagnose and differentiate in the emergency setting. The main diseases that manifest with chest pain include ischaemic heart disease, myocarditis, acute pericarditis, aortic dissection/rupture and pulmonary embolism (PE). Diseases that primarily present with dyspnoea include heart failure (HF), acute respiratory distress syndrome (ARDS), pneumonia, asthma exacerbations and chronic obstructive pulmonary disease. Pre-test probabilities of clinical findings play a vital part in diagnostic decisions, and the use of a Bayesian approach to these greatly improves the ability to stratify patients more accurately. However, blood tests (biomarkers) are increasingly used to assist in rapid decision-making in the emergency setting in combination with imaging methods such as chest radiograph, ultrasound and increasingly computed tomography, as well as physiological tests such as the electrocardiogram in addition to physical examination. Specific tests for ischaemic heart disease and myocarditis (cardiac troponins), HF (B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP)), aortic dissection (smooth muscle markers) and PE (D-dimer) have been developed. Surfactant protein-D and interleukin-8 have been developed for ARDS. Additionally, circulating microRNAs have emerged as promising biomarker candidates in cardiovascular disease. With this increasing array of biochemical markers to aid in the diagnosis of chest diseases presenting with chest pain and dyspnoea, we herein review the clinical usefulness of these markers, in particular in differentiating cardiac from pulmonary diseases. A symptom-oriented assessment as necessary for use in the critical setting is described in addition to discussion of individual biomarkers. |
| format | Default Article |
| id | rr-article-9620666 |
| institution | Loughborough University |
| publishDate | 2016 |
| record_format | Figshare |
| spelling | rr-article-96206662016-01-01T00:00:00Z Editor’s choice-Biomarkers of acute cardiovascular and pulmonary diseases Toru Suzuki (512729) Alexander Lyon (3498227) Rajeev Saggar (363674) Liam Heaney (5153435) Kenichi Aizawa (6475664) Antonio Cittadini (728881) Ciro Mauro (6031973) Rodolfo Citro (7243463) Giuseppe Limongelli (7243466) Francesco Ferrara (7243469) Olga Vriz (3663145) Andrew Morley-Smith (7243472) Paolo Calabro (7243475) Eduardo Bossone (3663130) Other health sciences not elsewhere classified Biomarkers Chest disease Critical care Medical and Health Sciences not elsewhere classified Acute cardiothoracic and respiratory diseases frequently remain a challenge to diagnose and differentiate in the emergency setting. The main diseases that manifest with chest pain include ischaemic heart disease, myocarditis, acute pericarditis, aortic dissection/rupture and pulmonary embolism (PE). Diseases that primarily present with dyspnoea include heart failure (HF), acute respiratory distress syndrome (ARDS), pneumonia, asthma exacerbations and chronic obstructive pulmonary disease. Pre-test probabilities of clinical findings play a vital part in diagnostic decisions, and the use of a Bayesian approach to these greatly improves the ability to stratify patients more accurately. However, blood tests (biomarkers) are increasingly used to assist in rapid decision-making in the emergency setting in combination with imaging methods such as chest radiograph, ultrasound and increasingly computed tomography, as well as physiological tests such as the electrocardiogram in addition to physical examination. Specific tests for ischaemic heart disease and myocarditis (cardiac troponins), HF (B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP)), aortic dissection (smooth muscle markers) and PE (D-dimer) have been developed. Surfactant protein-D and interleukin-8 have been developed for ARDS. Additionally, circulating microRNAs have emerged as promising biomarker candidates in cardiovascular disease. With this increasing array of biochemical markers to aid in the diagnosis of chest diseases presenting with chest pain and dyspnoea, we herein review the clinical usefulness of these markers, in particular in differentiating cardiac from pulmonary diseases. A symptom-oriented assessment as necessary for use in the critical setting is described in addition to discussion of individual biomarkers. 2016-01-01T00:00:00Z Text Journal contribution 2134/33313 https://figshare.com/articles/journal_contribution/Editor_s_choice-Biomarkers_of_acute_cardiovascular_and_pulmonary_diseases/9620666 CC BY-NC-ND 4.0 |
| spellingShingle | Other health sciences not elsewhere classified Biomarkers Chest disease Critical care Medical and Health Sciences not elsewhere classified Toru Suzuki Alexander Lyon Rajeev Saggar Liam Heaney Kenichi Aizawa Antonio Cittadini Ciro Mauro Rodolfo Citro Giuseppe Limongelli Francesco Ferrara Olga Vriz Andrew Morley-Smith Paolo Calabro Eduardo Bossone Editor’s choice-Biomarkers of acute cardiovascular and pulmonary diseases |
| title | Editor’s choice-Biomarkers of acute cardiovascular and pulmonary diseases |
| title_full | Editor’s choice-Biomarkers of acute cardiovascular and pulmonary diseases |
| title_fullStr | Editor’s choice-Biomarkers of acute cardiovascular and pulmonary diseases |
| title_full_unstemmed | Editor’s choice-Biomarkers of acute cardiovascular and pulmonary diseases |
| title_short | Editor’s choice-Biomarkers of acute cardiovascular and pulmonary diseases |
| title_sort | editor’s choice-biomarkers of acute cardiovascular and pulmonary diseases |
| topic | Other health sciences not elsewhere classified Biomarkers Chest disease Critical care Medical and Health Sciences not elsewhere classified |
| url | https://hdl.handle.net/2134/33313 |