Loading…
MicroRNAs: Micromanagers for the pathology of age related macular degeneration
Inflammation, oxidative stress, apoptosis and neovascularization are risky parameters which influence different phases in the pathogenesis of age related macular degeneration (AMD). Beside other mediators, this multitiered and complex event of retinal worsening has been exposed to be orchestrated by...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Default Article |
| Published: |
2018
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/2134/34110 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1818169480235188224 |
|---|---|
| author | Ritu Sharma Kanchan Mehta Sarabjit Mastana Monica Singh Puneetpal Singh |
| author_facet | Ritu Sharma Kanchan Mehta Sarabjit Mastana Monica Singh Puneetpal Singh |
| author_sort | Ritu Sharma (2689318) |
| collection | Figshare |
| description | Inflammation, oxidative stress, apoptosis and neovascularization are risky parameters which influence different phases in the pathogenesis of age related macular degeneration (AMD). Beside other mediators, this multitiered and complex event of retinal worsening has been exposed to be orchestrated by small non coding RNA fragments that bind to specific mRNAs and modulate their post transcriptional regulation and gene expression in retina. Several microRNAs (miRNAs) have been revealed which are expressed in retina and influence its functionality. These miRNA fragments play significant role in the development and maintenance of photoreceptors hence, dysregulation of them may augment severe retinal etiopathology. This comprehensive review summarizes the role and relevance of several known miRNAs along with their potential utilities as therapeutic targets in AMD pathogenesis. |
| format | Default Article |
| id | rr-article-9626108 |
| institution | Loughborough University |
| publishDate | 2018 |
| record_format | Figshare |
| spelling | rr-article-96261082018-01-01T00:00:00Z MicroRNAs: Micromanagers for the pathology of age related macular degeneration Ritu Sharma (2689318) Kanchan Mehta (7245935) Sarabjit Mastana (1249860) Monica Singh (7245941) Puneetpal Singh (3859297) Other health sciences not elsewhere classified MicroRNA Age related macular degeneration Inflammation Oxidative stress Angiogenesis Medical and Health Sciences not elsewhere classified Inflammation, oxidative stress, apoptosis and neovascularization are risky parameters which influence different phases in the pathogenesis of age related macular degeneration (AMD). Beside other mediators, this multitiered and complex event of retinal worsening has been exposed to be orchestrated by small non coding RNA fragments that bind to specific mRNAs and modulate their post transcriptional regulation and gene expression in retina. Several microRNAs (miRNAs) have been revealed which are expressed in retina and influence its functionality. These miRNA fragments play significant role in the development and maintenance of photoreceptors hence, dysregulation of them may augment severe retinal etiopathology. This comprehensive review summarizes the role and relevance of several known miRNAs along with their potential utilities as therapeutic targets in AMD pathogenesis. 2018-01-01T00:00:00Z Text Journal contribution 2134/34110 https://figshare.com/articles/journal_contribution/MicroRNAs_Micromanagers_for_the_pathology_of_age_related_macular_degeneration/9626108 CC BY-NC-ND 4.0 |
| spellingShingle | Other health sciences not elsewhere classified MicroRNA Age related macular degeneration Inflammation Oxidative stress Angiogenesis Medical and Health Sciences not elsewhere classified Ritu Sharma Kanchan Mehta Sarabjit Mastana Monica Singh Puneetpal Singh MicroRNAs: Micromanagers for the pathology of age related macular degeneration |
| title | MicroRNAs: Micromanagers for the pathology of age related macular degeneration |
| title_full | MicroRNAs: Micromanagers for the pathology of age related macular degeneration |
| title_fullStr | MicroRNAs: Micromanagers for the pathology of age related macular degeneration |
| title_full_unstemmed | MicroRNAs: Micromanagers for the pathology of age related macular degeneration |
| title_short | MicroRNAs: Micromanagers for the pathology of age related macular degeneration |
| title_sort | micrornas: micromanagers for the pathology of age related macular degeneration |
| topic | Other health sciences not elsewhere classified MicroRNA Age related macular degeneration Inflammation Oxidative stress Angiogenesis Medical and Health Sciences not elsewhere classified |
| url | https://hdl.handle.net/2134/34110 |