Search Results - Ambre, J~

  • Showing 1 - 8 results of 8
Refine Results
  1. 1
    The physical characterisation of a microscale parallel bioreactor platform with an industrial CHO cell line expressing an IgG4

    The physical characterisation of a microscale parallel bioreactor platform with an industrial CHO cell line expressing an IgG4 by Alvin W. Nienow, Chris Rielly, Kathryn Brosnan, Neil Bargh, Kenneth Lee, Karen Coopman, Christopher Hewitt

    Published 2013
    Subjects: Get full text
    Default Article
    Save to List
    Saved in:
  2. 2
    Process development of human multipotent stromal cell microcarrier culture using an automated high-throughput microbioreactor

    Process development of human multipotent stromal cell microcarrier culture using an automated high-throughput microbioreactor by Qasim A. Rafiq, Mariana P. Hanga, Thomas R.J. Heathman, Karen Coopman, Alvin W. Nienow, David Williams, Christopher J. Hewitt

    Published 2017
    “…At both scales, the agitation used during culture was the minimum required for microcarrier suspension, NJS . The use of the ambr15, with its improved control compared to the spinner flask, reduced the coefficient of variation on viable cell density in the serum containing medium from 7.65% to 4.08%, and the switch to serum free further reduced these to 1.06% and 0.54% respectively. …”
    Get full text
    Default Article
    Save to List
    Saved in:
  3. 3
    Production of erythrocytes from directly isolated or Delta1 Notch ligand expanded CD34 hematopoietic progenitor cells: process characterization, monitoring and implications for manufacture

    Production of erythrocytes from directly isolated or Delta1 Notch ligand expanded CD34 hematopoietic progenitor cells: process characterization, monitoring and implications for man... by Katie Glen, Victoria L. Workman, Forhad Ahmed, Elizabeth Ratcliffe, Adrian J. Stacey, Rob Thomas

    Published 2013
    “…High-resolution characterization of the process would identify production strategies for increased efficiency, monitoring and control. Methods: CD34 cord blood cells or equivalent cells that had been pre-expanded for 7 days with Delta1 Notch ligand were placed in erythroid expansion and differentiation conditions in a micro-scale ambr suspension bioreactor. …”
    Get full text
    Default Article
    Save to List
    Saved in:
  4. 4
    The productivity limit of manufacturing blood cell therapy in scalable stirred bioreactors

    The productivity limit of manufacturing blood cell therapy in scalable stirred bioreactors by Rachel Bayley, Forhad Ahmed, Katie Glen, Mark McCall, Adrian J. Stacey, Rob Thomas

    Published 2017
    “…O2 consumption was low (~5x10(-8) µg/cell.hr) theoretically enabling erythroblast densities in excess of 5x10(8) /ml in commercial bioreactors and sub-10 L/unit production volumes. …”
    Get full text
    Default Article
    Save to List
    Saved in:
  5. 5
    Agitation conditions for the culture and detachment of hMSCs from microcarriers in multiple bioreactor platforms

    Agitation conditions for the culture and detachment of hMSCs from microcarriers in multiple bioreactor platforms by Alvin W. Nienow, Christopher J. Hewitt, Thomas Heathman, Veronica A.M. Glyn, G. Fonte, Petra Hanga, Karen Coopman, Qasim A. Rafiq

    Published 2016
    “…In our recent work in different bioreactors up to 2.5 L in scale, we have successfully cultured hMSCs using the minimum agitator speed required for complete microcarrier suspension, NJS. …”
    Get full text
    Default Article
    Save to List
    Saved in:
  6. 6
    Supplementary figures for "Process development of human multipotent stromal cell microcarrier culture using an automated high-throughput microbioreactor"

    Supplementary figures for "Process development of human multipotent stromal cell microcarrier culture using an automated high-throughput microbioreactor" by Qasim A. Rafiq, Mariana P. Hanga, Thomas Heathman, Karen Coopman, Alvin Nienow, David Williams, Christopher Hewitt

    Published 2018
    “…At both scales, the agitation used during culture was the minimum required for microcarrier suspension, NJS. The use of the ambr15, with its improved control compared to the spinner flask, reduced the coefficient of variation on viable cell density in the serum containing medium from 7.65% to 4.08%, and the switch to serum free further reduced these to 1.06–0.54%, respectively. …”
    Get full text
    Data Data
    Save to List
    Saved in:
  7. 7
    Application of a simple unstructured kinetic and cost of goods models to support T-cell therapy manufacture

    Application of a simple unstructured kinetic and cost of goods models to support T-cell therapy manufacture by Maryam Shariatzadeh, Adriana G Lopes, Katie Glen, Andrew Sinclair, Rob Thomas

    Published 2021
    “…The models demonstrated that although glucose is a limiting factor in batch supplied medium, a delivery rate of glucose at significantly less than the maximal specific consumption rate (0.05 mg 1 ? …”
    Get full text
    Default Article
    Save to List
    Saved in:
  8. 8
    Supplementary Information Files for Application of a simple unstructured kinetic and cost of goods models to support T-cell therapy manufacture

    Supplementary Information Files for Application of a simple unstructured kinetic and cost of goods models to support T-cell therapy manufacture by Maryam Shariatzadeh, Adriana G Lopes, Katie Glen, Andrew Sinclair, Rob Thomas

    Published 2021
    “…The models demonstrated that although glucose is a limiting factor in batch supplied medium, a delivery rate of glucose at significantly less than the maximal specific consumption rate (0.05 mg 1 ? …”
    Get full text
    Data Data
    Save to List
    Saved in:

Search Tools: