Stem cells in degenerative orthopaedic pathologies: effects of aging on therapeutic potential by Kivanc Atesok, Freddie H. Fu, Ichiro Sekiya, Alexandra Stolzing, Mitsuo Ochi, Scott A. Rodeo

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The use of motion analysis to measure pain-related behaviour in a rat model of degenerative tendon injuries by Sai-Chuen Fu, Kai-Ming Chan, Lai-Shan Chan, Daniel Fong, Po-Yee Pauline Lui

“…In the end-point study, the rats were sacrificed to obtain tendon samples for histological examination after motion analyses. …”
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Preventing extrinsic mechanisms of bioprosthetic degeneration using polyphenols by Robert J Melder, Filippo Naso, Francesco Nicotra, Laura Russo, Ivan Vesely, Sugat R Tuladhar, Antonio M Calafiore, Peter Zilla, Alessandro Gandaglia, Sotiris Korossis

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The effects of pulsed electromagnetic field therapy on muscle strength and pain in patients with end-stage knee osteoarthritis: A randomized controlled trial by Qian-Wen Wang, Michael Tim-Yun Ong, Gene Chi-Wai Man, Alfredo Franco-Obregon, Ben Chi-Yin Choi, Pauline Po-Yee Lui, Daniel Fong, Ji-Hong Qiu, Xin He, Jonathan Patrick Ng, Patrick Shu-Hang Yung

“…Background: Osteoarthritis (OA) of the knee is one of the most common chronic degenerative joint conditions affecting aging population. …”
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The use of PRP injections in the management of knee osteoarthritis by Brendan O’Connell, Nick Wragg, Sammy Wilson

“…More uniformly positive results have been observed by various studies for PRP in OA knee in comparison to hyaluronic acid, other intra-articular injections and placebo than in other musculoskeletal tissue. …”
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Worker cooperatives as alternative economies within capitalism: organisational variation and democratic decision-making by Nicos Moushouttas

“…This thesis analyses the organisational and decision-making processes of worker cooperatives, which are productive organisations that are collectively owned and controlled by their worker-members. …”
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Overcoming the translational challenges of the effective administration and delivery of cells by Alexander M. Lyness, Nick Medcalf, David Williams

“…Many companies in regenerative medicine have designed their own delivery device often in series, not in parallel, with the development of their product. …”
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Rotator cuff repair augmentation using osteoinductive growth factors by Rhea S. Menon, Nicholas M. Wragg, Sammy Wilson

“…Here, growth factor candidates and delivery mechanisms are reviewed, specifically for improved RCI healing through enhanced bone ingrowth. In addition to BMPs, other potentially osteogenic factors including platelet-derived growth factors (PDGF), fibroblast growth factor (FGF), transforming growth beta isoforms (TGF-β1 and TGF-3) and parathyroid hormone (PTH) are evaluated since they can induce bone formation at the healing tendon attachment site. …”
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Effect of osteonal microstructure on crack propagation: a computational study by Mayao Wang

“…However, a study of the effect of morphological variations originating from different population groups, including those affected by pathological conditions such as osteoporosis, on fracture resistance of cortical bone was not performed. …”
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Bounded domain, bi-quadratic rational parametrisations of Dupin cyclides by Helmut Bez

“…The method is neither cyclide specific nor specific to the construction of bi-quadratic rational parametrisations - it may therefore be applied to other surfaces and to higher-degree rational constructions.…”
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Immobilization of Wnt fragment peptides on magnetic nanoparticles or synthetic surfaces regulate Wnt signaling kinetics by Bin Hu, Michael Rotherham, Neil Farrow, Paul Roach, Jon Dobson, Alicia J El Haj

“…Its diminished activation is implicated in osteoporosis and degenerative neural diseases. However, systematic administration of Wnt-signaling agonists carries risk, as aberrantly activated Wnt/β-catenin signaling is linked to cancer. …”
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Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies by Alexandra Stolzing, E. Jones, D. McGonagle, Andrew Scutt

“…These data suggest that hMSC numbers obtained by marrow aspiration decline with age. Furthermore, there is an age-related decline in overall BM MSC "fitness" which might lead to problems when using autologous aged MSC for cell-based therapies. © 2007 Elsevier Ireland Ltd. …”
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The game of (your) life: professional rugby careers by Christine Coupland

“…This kind of immersion requires alternatives to be, temporarily at least, silenced and in this context renders the accrual of bodily capital as fit, but only temporarily fit for purpose.…”
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The association between dietary intake of folate (F) and vitamin B12 (VB12) with body composition (BC) of adolescents aged 10-18 years from Merida, Mexico by Maria L. Avila-Escalante

“…Paradoxically, too many Mexican children and adolescents are currently overweight or obese (OW/OB). The dual-burden of stunting (low height for age) and OW/OB are nutritional conditions that increase the risk of developing chronic degenerative diseases in adulthood. …”
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The medical management of patients with chronic plantar fasciitis by Patrick Wheeler

“…JAAOS - Journal of the American Academy of Orthopaedic Surgeons. 2008;16(6):338-46.2. Orchard J. …”
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Tissue engineering strategies for the development of a human 3D model of the neuromuscular junction by Lucia Marani

“…This can be further optimised for applications such as drug screening, personalised medicine testing, or disease modeling.…”
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Characterising variability and regional correlations of microstructure and mechanical competence of human tibial trabecular bone: An in-vivo HR-pQCT study by Juan Du, Katherine Brooke-Wavell, Margaret A. Paggiosi, C. Hartley, Jennifer S. Walsh, Vadim Silberschmidt, Simin Li

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Design and additive manufacture of microphysiological perfusion systems for pharmaceutical screening of tissue engineered skeletal muscle by Rowan P. Rimington

“…Furthermore, work is also required to optimise the biological environment prior to mass manufacture. …”
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Cryopreservation of human umbilical cord-derived mesenchymal stem cells in complex sugar based cryoprotective solutions by Yahaira Naaldijk, Viktoriya Federova, Alexandra Stolzing

“…Mesenchymal stem cells (MSCs) are able to differentiate in vivo and in vitro giving rise to different cell types including osteoblasts, adipocytes, chondrocytes and neuronal cells, providing a valuable source for treatment of degenerative and age-associated diseases. …”
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Modelling the efficiency of terrestrial photovoltaic systems by Ian R. Cole, Ralph Gottschalg

“…It is demonstrated that the simulation is a useful tool in the optimization of proposed system designs, the analysis of electrical performance and, moreover, the prediction of the occurrence of degenerative system effects such as hot-spots. …”
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Biomarkers to identify and isolate senescent cells. by Mantas Matjusaitis, Greg Chin, Ethan Anders Sarnoski, Alexandra Stolzing

“…Therefore, this will not be a comprehensive review of all senescence biomarkers but rather an outlook on technologies and markers that are most suitable to identify and isolate senescent cells.…”
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The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review by Mishti Khatri, Robert J Naughton, Tom Clifford, Liam D Harper, Liam Corr

“…Exact mechanisms for these adaptations are unclear, with future research using larger sample sizes, elite athletes, female participants and more precise outcome measures such as muscle biopsies and magnetic imagery.…”
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Suspension cultures of bone-marrow-derived mesenchymal stem cells: effects of donor age and glucose level by Alexandra Stolzing, Eva Bauer, Andrew Scutt

“…MSC cultures isolated from 3- and 12-month-old rats were maintained using the "pour-off" method for up to 14 days in media containing different glucose levels and the phenotype, growth characteristics, colony forming unit-fibroblastic (CFU-f) numbers, and pluripotency characteristics of these cells were determined. …”
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Effect of micromorphology of cortical bone tissue on crack propagation under dynamic loading by Mayao Wang, Xing Gao, Adel A. Abdel-Wahab, Simin Li, Elizabeth A. Zimmermann, Christoph Riedel, Bjorn Busse, Vadim Silberschmidt

“…In addition, ageing and degenerative bone diseases such as osteoporosis can increase the risk of fracture [1]. …”
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Distribution pattern following systemic mesenchymal stem cell injection depends on the age of the recipient and neuronal health by Claire Fabian, Yahaira Naaldijk, Christiane Leovsky, Adiv A. Johnson, Lukas Rudolph, Carsten Jaeger, Katrin Arnold, Alexandra Stolzing

“…In contrast, young MSCs that were transplanted into aged mice were only found in the brain cortex. In both young and aged mouse recipients, transplantation of aged MSCs showed biodistribution only in the blood and spleen. …”
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