Enantioselective Induction of Cytotoxicity by o,p′‑DDD in PC12 Cells: Implications of Chirality in Risk Assessment of POPs Metabolites

The increased release of chiral persistent organic pollutants (POPs) into the environment has resulted in more attention to the role of enantioselectivity in the fate and ecotoxicological effects of these compounds. Although the enantioselectivity of chiral POPs has been considered in previous studi...

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Bibliographic Details
Published in:	Environmental science & technology 2013-04, Vol.47 (8), p.3909-3917
Main Authors:	Wang, Cui, Li, Zhuoyu, Zhang, Quan, Zhao, Meirong, Liu, Weiping
Format:	Article
Language:	English
Subjects:	Air Pollutants - chemistry Air Pollutants - toxicity Animals Antioxidants - metabolism Apoptosis Apoptosis - drug effects Apoptosis - genetics Biological and medical sciences Cells Chemical compounds Chromatography, High Pressure Liquid Cytotoxicity Dichlorodiphenyldichloroethane - chemistry Dichlorodiphenyldichloroethane - isolation & purification Dichlorodiphenyldichloroethane - toxicity ecotoxicology enantiomers Enzyme-Linked Immunosorbent Assay enzymes ethanol Gene Expression Regulation - drug effects Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Medical sciences Metabolites microarray technology Oligonucleotide Array Sequence Analysis Organic contaminants oxidative stress Oxidative Stress - drug effects Oxidative Stress - genetics PC12 Cells persistent organic pollutants Pesticides, fertilizers and other agrochemicals toxicology Rats Reproducibility of Results Reverse Transcriptase Polymerase Chain Reaction Risk Assessment Rodents Stereoisomerism structure-activity relationships Toxicology Tumor Suppressor Protein p53 - metabolism
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