Injection Route and TLR9 Agonist Addition Significantly Impact Heroin Vaccine Efficacy

Active immunization is an effective means of blocking the pharmacodynamic effects of drugs and holds promise as a treatment for heroin addiction. Previously, we demonstrated the efficacy of our first-generation vaccine in blocking heroin self-administration in rats, however, many vaccine components...

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Bibliographic Details
Published in:Molecular pharmaceutics 2014-03, Vol.11 (3), p.1075-1080
Main Authors: Bremer, Paul T, Schlosburg, Joel E, Lively, Jenny M, Janda, Kim D
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - administration & dosage
Alum Compounds - administration & dosage
Analgesics - administration & dosage
Animals
Antibodies - blood
Antibodies - immunology
Brief
Drug Administration Routes - veterinary
Enzyme-Linked Immunosorbent Assay
Heroin - administration & dosage
Heroin - immunology
Heroin Dependence - blood
Heroin Dependence - immunology
Heroin Dependence - prevention & control
Immunization - methods
Injections, Intraperitoneal
Injections, Intravenous
Injections, Subcutaneous
Male
Mice
Oligodeoxyribonucleotides - pharmacology
Rats
Toll-Like Receptor 9 - agonists
Vaccines, Conjugate - administration & dosage
Vaccines, Conjugate - chemistry
Vaccines, Conjugate - immunology
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