BNP-Guided vs Symptom-Guided Heart Failure Therapy: The Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) Randomized Trial

CONTEXT It is uncertain whether intensified heart failure therapy guided by N-terminal brain natriuretic peptide (BNP) is superior to symptom-guided therapy. OBJECTIVE To compare 18-month outcomes of N-terminal BNP–guided vs symptom-guided heart failure therapy. DESIGN, SETTING, AND PATIENTS Randomi...

Full description

Saved in:
Bibliographic Details
Published in:JAMA : the journal of the American Medical Association 2009-01, Vol.301 (4), p.383-392
Main Authors: Pfisterer, Matthias, Buser, Peter, Rickli, Hans, Gutmann, Marc, Erne, Paul, Rickenbacher, Peter, Vuillomenet, André, Jeker, Urs, Dubach, Paul, Beer, Hansjürg, Yoon, Se-Il, Suter, Thomas, Osterhues, Hans H, Schieber, Michael M, Hilti, Patrick, Schindler, Ruth, Brunner-La Rocca, Hans-Peter, TIME-CHF Investigators, for the
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - administration & dosage
Aged
Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors - administration & dosage
Biological and medical sciences
Biomarkers - blood
Cardiology. Vascular system
Cardiovascular Agents - administration & dosage
Clinical trials
Digoxin - administration & dosage
Disease-Free Survival
Diuretics - administration & dosage
Female
General aspects
Germany
Heart
Heart failure
Heart Failure - blood
Heart Failure - drug therapy
Heart Failure - physiopathology
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Hospitalization
Humans
Male
Medical sciences
Middle Aged
Multivariate Analysis
Natriuretic Peptide, Brain - blood
Natriuretic Peptide, Brain - drug effects
Nitrates - administration & dosage
Odds Ratio
Older people
Peptide Fragments - blood
Peptide Fragments - drug effects
Proportional Hazards Models
Quality of Life
Severity of Illness Index
Stroke Volume
Surveys and Questionnaires
Switzerland
Therapy
Treatment Outcome
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!