Synthesis of 7H-Benzo[e]naphtho[1,8-bc]silines by Rhodium-catalyzed [2 + 2 + 2] Cycloaddition

An efficient synthesis of 7H-benzo[e]naphtho[1,8-bc]silines has been developed by a rhodium-catalyzed [2 + 2 + 2] cycloaddition of alkynyl(8-alkynyl-1-naphthyl)silanes with internal alkynes. High chemoselectivity can be realized by employing P(2-MeOC6H4)3 as the ligand for rhodium. Preliminary inves...

Full description

Saved in:
Bibliographic Details
Published in:Chemistry letters 2020-04, Vol.49 (4), p.344-346
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An efficient synthesis of 7H-benzo[e]naphtho[1,8-bc]silines has been developed by a rhodium-catalyzed [2 + 2 + 2] cycloaddition of alkynyl(8-alkynyl-1-naphthyl)silanes with internal alkynes. High chemoselectivity can be realized by employing P(2-MeOC6H4)3 as the ligand for rhodium. Preliminary investigation of its asymmetric variant has also been described to create a silicon stereogenic center with relatively high enantioselectivity.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.200025