Superior ligand for Pd（II）-catalyzed enantioselective arylation of C（spa）-H bonds： chiral acetyl protected aminoethyl quinoline

Enantioselective functionalization of prochiral C-H bonds is a highly attractive strategy for the construction of chiral compounds.Despite extensive efforts[1],enantioselective C（sp3）-H functionalization still remains challenging at present.For instance,although enantioselective C-H functionalizatio...

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Bibliographic Details
Published in:中国科学：化学英文版 2017, Vol.60 (2), p.165-166
Main Author: Zheng-Yang Xu Hai-Zhu Yu Yao Fu
Format: Article
Language:English
Subjects:
SPA
不对称反应
乙酰基
催化
对映选择性
手性化合物
氨基喹啉
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Summary:Enantioselective functionalization of prochiral C-H bonds is a highly attractive strategy for the construction of chiral compounds.Despite extensive efforts[1],enantioselective C（sp3）-H functionalization still remains challenging at present.For instance,although enantioselective C-H functionalization via desymmetrization of two carbon centers has been accomplished with Pd catalysis and a directing group,differenciation of the prochiral C-H bonds on one methylene carbon center has rarely been achieved.On a different front,introduction of a transient chiral directing group is expected to be useful in enantioselective C-H arylation of C（sp2）-H bonds.Nevertheless,
ISSN:1674-7291
1869-1870