Over-expression of CD163, CD169, and CD151 is not sufficient to improve the susceptibility to porcine reproductive and respiratory syndrome virus infection in transgenic mice

<正>Porcine reproductive and respiratory syndrome virus(PRRSV)is a major pathogen that causes reproductive failure and respiratory disease in pigs,resulting in devastating economic losses worldwide[1].Porcine alveolar macrophages(PAMs)are the primary target cells of PRRSV[2],and the put...

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Published in:科学通报：英文版 2017 (24), p.1634-1636
Main Author: Zhengzhi Cui Shuaishuai Niu Jingjing Liu Lei Xu Yunping Dai Ning Li Youmin Kang Linlin Zhang Lei Zhou Shuyang Yu
Format: Article
Language:English
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Summary:<正>Porcine reproductive and respiratory syndrome virus(PRRSV)is a major pathogen that causes reproductive failure and respiratory disease in pigs,resulting in devastating economic losses worldwide[1].Porcine alveolar macrophages(PAMs)are the primary target cells of PRRSV[2],and the putative receptors,including CD163,CD169,and CD151,play key roles during infection[3–6].However,the understanding of PRRSV infection and pathogenesis is limited
ISSN:2095-9273