Anesthesia‐related brain microstructure modulations detected by diffusion magnetic resonance imaging

Recent studies have shown significant changes to brain microstructure during sleep and anesthesia. In vivo optical microscopy and magnetic resonance imaging (MRI) studies have attributed these changes to anesthesia and sleep‐related modulation of the brain's extracellular space (ECS). Isofluran...

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Bibliographic Details
Published in:NMR in biomedicine 2024-07, Vol.37 (7), p.e5033-n/a
Main Authors: Lindhardt, Thomas Beck, Skoven, Christian Stald, Bordoni, Luca, Østergaard, Leif, Liang, Zhifeng, Hansen, Brian
Format: Article
Language:English
Subjects:
Anesthesia
Animals
awake
Brain
Brain - diagnostic imaging
Brain - drug effects
Cell size
Diffusion Magnetic Resonance Imaging
DKI
Edema
Extracellular matrix
extracellular space
glymphatic
In vivo methods and tests
Isoflurane
Isoflurane - pharmacology
Kurtosis
Light microscopy
Magnetic resonance imaging
Male
Medical imaging
Mice
Mice, Inbred C57BL
Microstructure
mouse
MRI
Neuroimaging
Optical microscopy
Sleep
Sleep and wakefulness
Substantia alba
Substantia grisea
Wakefulness - physiology
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Summary:Recent studies have shown significant changes to brain microstructure during sleep and anesthesia. In vivo optical microscopy and magnetic resonance imaging (MRI) studies have attributed these changes to anesthesia and sleep‐related modulation of the brain's extracellular space (ECS). Isoflurane anesthesia is widely used in preclinical diffusion MRI (dMRI) and it is therefore important to investigate if the brain's microstructure is affected by anesthesia to an extent detectable with dMRI. Here, we employ diffusion kurtosis imaging (DKI) to assess brain microstructure in the awake and anesthetized mouse brain (n = 22). We find both mean diffusivity (MD) and mean kurtosis (MK) to be significantly decreased in the anesthetized mouse brain compared with the awake state (p 
ISSN:0952-3480
1099-1492
1099-1492
DOI:10.1002/nbm.5033