Lupusnefritt og langtidsprognose ved systemisk lupus erythematosus

• Main Author: Moe, Sigrid Elise Reppe
• Format: Dissertation
• Language: Norwegian

Background and aims: Systemic lupus erythematous (SLE) is a systemic autoimmune disease, which is heterogenic in manifestation and with a variable clinical course. With the last thirty years advances in new medical treatment in the field, the overall survival in SLE has improved tremendously. However, SLE can still be a devastating disease resulting in early death. Lupus nephritis (LN) remains one of the most common and severe manifestations of SLE. In this review the aim is to illustrate how lupus nephritis influences the overall prognosis in systemic lupus erythematous and to identify potential risk factors for death. Methods: This is a review. Articles were found by targeted searches for relevant publications in PubMed until summer 2015. Mainly focus was on articles published after 2000. The following search terms were systemic lupus erythematous and lupus nephritis in combinations with the terms mortality , morbidity , risk factors , SMR , ESRD and long-time prognosis . Relevant articles from the bibliography of included articles and systematic reviews were also included. Results: LN is associated with a worse outcome of SLE, including development of end stage renal disease (ESRD) and an increased risk of death. Risk factors for death are found to be renal damage and ESRD. Other investigated aspect, such as the effect of ethnicity and histological class of LN, shows inconsistent results. Renal preservation through early intervention and treatment are essential for favorable patient outcomes. Conclusion: LN is a risk factor for increased morbidity and mortality in SLE. However, more population-based research is needed to understand to which degree LN impacts the long-time prognosis of SLE.