Pregnancy and postpartum levels of circulating maternal sHLA-G in preeclampsia

•Circulating maternal sHLA-G is reduced in early- and late-onset preeclampsia.•Elevated sFlt-1 is independently associated with low sHLA-G in women with preeclampsia and gestational hypertension.•Circulating maternal sHLA-G is elevated after pregnancy complicated by early-onset preeclampsia. Preecla...

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Bibliographic Details
Published in:Journal of reproductive immunology 2021-02, Vol.143, p.103249-103249, Article 103249
Main Authors: Jacobsen, Daniel P., Lekva, Tove, Moe, Kjartan, Fjeldstad, Heidi E.S., Johnsen, Guro Mørk, Sugulle, Meryam, Staff, Anne Cathrine
Format: Article
Language:English
Subjects:
Angiogenic biomarkers
Immunology
PlGF
Preeclampsia
sFlt-1
sHLA-G
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Summary:•Circulating maternal sHLA-G is reduced in early- and late-onset preeclampsia.•Elevated sFlt-1 is independently associated with low sHLA-G in women with preeclampsia and gestational hypertension.•Circulating maternal sHLA-G is elevated after pregnancy complicated by early-onset preeclampsia. Preeclampsia is a leading cause of maternal and offspring mortality and morbidity, and predicts increased future cardiovascular disease risk. Placental dysfunction and immune system dysregulation are likely key pathophysiological factors. Soluble human leukocyte antigen G (sHLA-G) may dampen the specific immune response towards placental trophoblasts. Previous studies have shown low sHLA-G levels in preeclampsia, but postpartum, levels are unknown. Furthermore, the relationship between sHLA-G and sFlt-1 and PlGF, placental function markers, is unknown. We hypothesized that low maternal sHLA-G during pregnancy would be associated with placental dysfunction, including preeclampsia, gestational hypertension, and dysregulated sFlt-1 and PlGF, and that sHLA-G would remain decreased following preeclampsia. We included 316 pregnant women: 58 with early-onset preeclampsia (
ISSN:0165-0378
1872-7603
DOI:10.1016/j.jri.2020.103249