Lifetime obesity trends are associated with subclinical myocardial injury: The Trøndelag health study

Background Obesity is associated with subclinical myocardial injury as quantified by concentrations of cardiac troponin T, but whether lifetime excess weight history is associated with increased concentrations of cardiac troponin I (cTnI) and how indices of abdominal adiposity and glycemic dysregula...

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Bibliographic Details
Published in:Journal of internal medicine 2022-03, Vol.291 (3), p.317-326
Main Authors: Lyngbakken, Magnus Nakrem, Lemos, James A., Hveem, Kristian, Røsjø, Helge, Omland, Torbjørn
Format: Article
Language:English
Subjects:
Abdomen
Adipose tissue
Biomarkers - metabolism
Body weight
Calcium-binding protein
cardiovascular risk factors
Clusters
epidemiology
Female
Glucose metabolism
Health risks
Heart
Heart Failure - complications
Humans
Injuries
Obesity
Obesity - complications
Obesity - epidemiology
Odds Ratio
Overweight
Trends
Troponin
Troponin I
Troponin T
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Summary:Background Obesity is associated with subclinical myocardial injury as quantified by concentrations of cardiac troponin T, but whether lifetime excess weight history is associated with increased concentrations of cardiac troponin I (cTnI) and how indices of abdominal adiposity and glycemic dysregulation affect these associations remain unclear. Methods We analyzed cTnI with a high‐sensitivity assay in 9739 participants in the Trøndelag Health (HUNT) Study at study visit 4 (2017–2019). BMI was assessed at study Visit 1 (1984–1986), 2 (1995–1997), 3 (2006–2008), and 4. Results Median age at visit 4 was 68.7 years and 59% were women. Concentrations of cTnI were detectable in 84.1% of study participants, with a median of 2.5 (1.5–4.5 ng/L). We identified three clusters of BMI trajectories from visit 1 to 4, (1) stable normal weight, (2) stable overweight, and (3) stable obesity. Participants in clusters 2 and 3 were at increased risk of elevated concentrations of cTnI at visit 4 (odds ratio 1.27, 95% CI 1.09–1.47, and odds ratio 1.70, 95% CI 1.33–2.17, p for trend
ISSN:0954-6820
1365-2796
DOI:10.1111/joim.13391