Acyclic Cucurbit[n]uril-Type Molecular Containers Bind Neuromuscular Blocking Agents In Vitro and Reverse Neuromuscular Block In Vivo

Be My Guest: Two acyclic cucurbit[n]uril‐type receptors that carry SO3−‐groups bind tightly to several commonly used neuromuscular blocking agents, such as rocuronium, in aqueous solution as revealed by direct and competitive UV/Vis binding assays. One of these containers functions as a potent rever...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2012-11, Vol.51 (45), p.11358-11362
Main Authors: Ma, Da, Zhang, Ben, Hoffmann, Ulrike, Sundrup, Martina Grosse, Eikermann, Matthias, Isaacs, Lyle
Format: Article
Language:English
Subjects:
Animals
Bridged-Ring Compounds - pharmacology
cucurbit[n]uril
host-guest systems
Humans
Imidazoles - pharmacology
Kinetics
medicinal chemistry
Models, Molecular
molecular recognition
Neuromuscular Blockade - methods
neuromuscular blocking agents
Neuromuscular Blocking Agents - pharmacology
Neuromuscular Junction - drug effects
Neuromuscular Junction - metabolism
Rats
Spectrophotometry, Ultraviolet
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