Homologous recombination deficiency in breast cancer: Implications for risk, cancer development, and therapy

An underlying cause of breast cancers has been largely attributed to defects in the DNA damage response (DDR) pathway. In particular, the homologous recombination (HR) pathway repairs double‐stranded breaks (DSBs) in DNA, ultimately protecting the cell from genomic instability and thus preventing th...

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Bibliographic Details
Published in:Genes chromosomes & cancer 2021-05, Vol.60 (5), p.358-372
Main Authors: Ali, Rayhaan M. M., McIntosh, Stuart A., Savage, Kienan I.
Format: Article
Language:English
Subjects:
Animals
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - genetics
Breast Neoplasms - pathology
chemotherapy
Clinical trials
Deoxyribonucleic acid
DNA
DNA damage
DNA repair
Female
Genetic Testing - methods
Genomic instability
Germ-Line Mutation
Homologous recombination
Humans
Molecular Targeted Therapy - methods
Mutation
PARP inhibitors
Poly(ADP-ribose) polymerase
Recombinational DNA Repair
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