Macrophages-Key cells in the response to wear debris from joint replacements

The generation of wear debris is an inevitable result of normal usage of joint replacements. Wear debris particles stimulate local and systemic biological reactions resulting in chronic inflammation, periprosthetic bone destruction, and eventually, implant loosening, and revision surgery. The latter...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2013-10, Vol.101 (10), p.3033-3045
Main Authors: Nich, Christophe, Takakubo, Yuya, Pajarinen, Jukka, Ainola, Mari, Salem, Abdelhakim, Sillat, Tarvo, Rao, Allison J., Raska, Milan, Tamaki, Yasunobu, Takagi, Michiaki, Konttinen, Yrjö T., Goodman, Stuart B., Gallo, Jiri
Format: Article
Language:English
Subjects:
Animals
Arthroplasty, Replacement - adverse effects
aseptic loosening
Biological and medical sciences
Cell Communication
Humans
inflammation
Macrophages - cytology
Medical sciences
Models, Biological
monocyte/macrophage
Monocytes - cytology
Orthopedic surgery
osteolysis
Prosthesis Failure - adverse effects
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology. Biomaterials. Equipments
tissue homeostasis
total joint replacement
wear particles
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