Lactobacillus paracasei IMC 502 ameliorates type 2 diabetes by mediating gut microbiota–SCFA–hormone/inflammation pathway in mice

BACKGROUND Type 2 diabetes mellitus (T2DM) is a complex and prevalent metabolic disease that seriously threatens human health. Numerous studies have shown that probiotics as dietary supplements have the potential to prevent and treat T2DM. However, the ability of various strains to improve diabetes...

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Bibliographic Details
Published in:	Journal of the science of food and agriculture 2023-04, Vol.103 (6), p.2949-2959
Main Authors:	Gu, Yuxiang, Chen, Haoran, Li, Xing, Li, Dan, Sun, Yue, Yang, Lin, Ma, Ying, Chan, Eric Chun Yong
Format:	Article
Language:	English
Subjects:	1-Phosphatidylinositol 3-kinase Aged agriculture AKT protein Animals Blood glucose Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Experimental Diabetes Mellitus, Type 2 - metabolism Diet Dietary supplements digestive system elderly Fatty acids feces Gastrointestinal Hormones Gastrointestinal Microbiome Gene expression Gluconeogenesis Glucose Glucose tolerance gut microbiota Health risks Hormones human health Humans Inflammation Inflammatory response Insulin Insulin resistance Intestinal microflora intestinal microorganisms Intolerance L. paracasei IMC 502 Lacticaseibacillus paracasei Lactobacilli Lactobacillus paracasei Lipids Lipogenesis Liver Metabolic disorders Mice Microbiomes Microbiota mRNA noninsulin-dependent diabetes mellitus Pharmacodynamics Pharmacology Phosphatidylinositol 3-Kinases Probiotics Probiotics - metabolism protein synthesis secretion short‐chain fatty acid Signs and symptoms type 2 diabetes mellitus
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