Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma

Comprehensive multiplatform analysis of 80 uveal melanomas (UM) identifies four molecularly distinct, clinically relevant subtypes: two associated with poor-prognosis monosomy 3 (M3) and two with better-prognosis disomy 3 (D3). We show that BAP1 loss follows M3 occurrence and correlates with a globa...

Full description

Saved in:

Bibliographic Details
Published in:	Cancer cell 2017-08, Vol.32 (2), p.204-220.e15
Main Authors:	Robertson, A. Gordon, Gibb, Ewan A., Oba, Junna, Uzunangelov, Vladislav, Walter, Vonn, Danilova, Ludmila, Kimes, Patrick K., Babur, Ozgun, Akbani, Rehan, Bristow, Christopher A., Iype, Lisa, Beroukhim, Rameen, Bowen, Jay, Bowlby, Reanne, Carlsen, Rebecca, Cebulla, Colleen M., Chin, Lynda, Chuah, Eric, Chudamani, Sudha, Cibulskis, Carrie, Cibulskis, Kristian, Cope, Leslie, Coupland, Sarah E., Defreitas, Timothy, Demchok, John A., Desjardins, Laurence, Esmaeli, Bita, Felau, Ina, Ferguson, Martin L., Frazer, Scott, Gehlenborg, Nils, Gerken, Mark, Getz, Gad, Griewank, Klaus G., Heiman, David I., Helsel, Carmen, Hu, Xin, Jefferys, Stuart R., Leraas, Kristen M., Lichtenberg, Tara M., Liu, Jia, Ma, Yussanne, Mariani, Odette, Marra, Marco A., Meier, Sam, Meyerson, Matthew, Mungall, Andrew J., Mungall, Karen L., Murray, Bradley A., Naresh, Rashi, Pantazi, Angeliki, Parfenov, Michael, Park, Peter J., Protopopov, Alexei, Radenbaugh, Amie, Rai, Karan, Ramirez, Nilsa C., Ren, Xiaojia, Reynolds, Sheila M., Roach, Jeffrey, Schadendorf, Dirk, Schumacher, Steven E., Seidman, Jonathan, Seth, Sahil, Sethi, Geetika, Sheth, Margi, Shi, Yan, Singh, Arun D., Sipahimalani, Payal, Soloway, Matthew G., Sun, Huandong, Tan, Donghui, Tang, Ming, Tse, Kane, Verhaak, Roel G.W., Wan, Yunhu, Weinstein, John N., Williams, Michelle D., Woodman, Scott E., Yang, Liming, Yang, Lixing, Yau, Christina, Zhang, Hailei, Zmuda, Erik, Benz, Christopher, Mills, Gordon B., Gershenwald, Jeffrey E., Schoenfield, Lynn, Abdel-Rahman, Mohamed H., Stern, Marc-Henri
Format:	Article
Language:	English
Subjects:	Biomarkers, Tumor - genetics DNA Copy Number Variations DNA Methylation EIF1AX Eukaryotic Initiation Factor-1 - genetics Gene Expression Regulation, Neoplastic GNA11 GNAQ Humans Melanoma - classification Melanoma - genetics molecular subtypes Monosomy monosomy 3 Mutation noncoding RNA Phosphoproteins - genetics Prognosis RNA Splicing Factors - genetics Serine-Arginine Splicing Factors - genetics SF3B1 SRSF2 TCGA Tumor Suppressor Proteins - genetics Ubiquitin Thiolesterase - genetics uveal melanoma Uveal Neoplasms - classification Uveal Neoplasms - genetics
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!